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1、云克联合治疗原发性骨质疏松症的临床分析刘枫(广东广州肿瘤医院核医学科广东广州510060)【中图分类号】R969【文献标识码】A【文章编号】1672-5085(2012)24-0160-03【摘要】目的探讨云克与钙剂、维生素联合治疗骨质疏松症的临床疗效。方法70例骨质疏松症患者分为治疗组35例和对照组35例，治疗组采用云克5.5mg缓慢静脉推注,1次/d,20d。间隔1周后开始下一疗程。共4个疗程。同时口服钙尔奇D,1片/d,持续成用半年。对照组皮用钙尔奇D,1片/d。治疗前和治疗后6个月分别检测尺桡骨值及BGP、PYD变化。结果治疗组疼痛缓解率71.4%明显高于对照组34.2
2、%(χ2=3.84,P<0.05)；治疗前后治疗组尺、桡骨BMD变化率分别为15.2%和13.9%,明显高于对照组3.6%和4.0%(χ2=3.94,χ2=3.85,P均<0.05)；治疗组和对照组BGP和PYD治疗前后变化率分别为23.0%和35.8%,(χ2=4.01,P<0.05)；治疗组有效率75.0%明显高于对照组37.1%(χ2=3.98,P<0.05)o结论云克与钙剂、维生素D3联合治疗可以降低骨折危险度。【关键词】99锝-亚甲基二膦酸盐钙维生素D3骨质疏松治疗Clinicalanalysisofpr
3、imaryosteoporosisbycombinationtherapywith99TC-MDP[Abstract]ObjectiveToexploretheclinicaleffectofcombinatontherapyofYunke(99technetiummethylenediphosphonate,99Tc-MDP)onprimaryosteoporosis.MethodsSeventypatientssufferedfromprimaryosteoporosiswererandomizedintotreatmentgroup(n=35)andcontrolgrou
4、p(n=35).Treatmentgroupweretreatedwithtreatmentprot°CoIsincludedYunke(5.5mgofYunkewasinjectedslowlythroughveineverydayfortwentytimesandsubsequentlywithanintermissionforoneweek,repeatedfourtimes),calciumcarbonate(1.5g,oncedaily)andvitaminD3(125u,oncedaily)forsixmonth.Controlgroupweretreatedwit
5、hcalciumcarbonate(1.5g/oncedaily)andvitaminD3(125u,oncedaily)forsixmonth.TheulnaandradiusBMD,serumboneglaproteinandurinepyridino-linebetweenthetwogroupswerecompared.ResultsTherateofpainrelief71.4%intreatmentgroupweresignificantlyhigherthanthat34.2%incontrolgroup(χ2=3.84，P<O.O5);Thecha
6、ngeratesofBMDwithulnarandradial15.2%and13.9%intreatmentgroupweresignificantlyhigherthanthe3.6%and4.0%incontrolgroup(χ2=3.94,χ2=3.85，P<0.05);TherateofchangeofBGPandPYDbeforeandaftertreatmentinthetreatmentgroupandcontrolgroupwere23.0%and35.8%respcctively(χ2=4.01，P<0.05);Rateo
7、feffect75.0%intreatmentgroupweresignificantlyhigherthanthatof37.1%incontrolgroup(χ2=3.98P<0.05);ConclusionCombinationtherapyofYunke,calciumandvitainD3canreducingtheriskoffractureinpatientswithprimaryosteoporosis.【Keywords]99technetiummethyle
