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1、阿托伐他汀钙与辛伐他汀治疗颈动脉粥样硬化斑块患者疗效的观察(1•四川省郸县人民医院神经内科四川成都611730；2.四川省人民医院神经内科四川成都610072)【摘要】冃的：探讨阿托伐他汀钙与辛伐他汀治疗颈动脉粥样硬化的疗效。方法：收集我院2014年1月至2015年2月住院及门诊的80例颈动脉粥样硬化患者随机分为两组。辛伐他汀组给予口服辛伐他汀治疗，阿托伐他汀钙组给予口服阿托伐他汀钙治疗，比较两组患者治疗前后斑块相关指标、IMT、血脂与相关分子指标。结果：阿托伐他汀钙组患者治疗后斑块直径、斑块厚
2、度、斑块面积、硬斑比例、IMT、TG、TC、LDL・C、BNP、Hs-CRP与MCP・1水平组间比较显著性低于辛伐他汀组，软斑比例与HDL・C水平显著性高于辛伐他汀组，存在显著性差异,具有统计学意义(P<0.01)o结论：阿托伐他汀钙与辛伐他汀均具有显著调脂疗效，但相同条件下阿托伐他汀钙调节血脂的疗效强于辛伐他汀；阿托伐他汀钙与辛伐他汀均能减小颈动脉斑块直径、斑块厚度、斑块面积、硬斑比例、颈动脉内冲层厚度(IMT),降低BNP、Hs-CRP与MCP・1从而起到抗动脉粥样硬化的作用，但相同条
3、件下阿托伐他汀钙的抗动脉粥样硬化效果强于辛伐他汀。【关键词】阿托伐他汀钙；辛伐他汀；颈动脉粥样硬化；血脂ComparisonoftheeffectsofatorvastatinandsimvastatininthetreatmentofcarotidatherosclerosisYuanWei1,GaoChunLinglJangJuanjuan1,FengXiang2(l.Pixianpeople'sHospitalofSichuanSichuanChengdu611730;2.Departme
4、ntofinternalmedicineSichuanChengdu610072)[Abstract]Objective:Toinvestigatetheefficacyofatorvastatincalciumandsimvastatininthetreatmentofcarotidatherosclerosis.Method:80patientswithcarotidatherosclerosiswererandomlydividedintotwogroupsfromFebruary2015
5、toJanuary2014.Thecontrolgroupreceivedoralsimvastatintreatment,theatorvastatingroupwasgivenatorvastatincalciumtreatment,comparedwithtwogroupsofpatientsbeforeandaftertreatmentofplaquerelatedindicators,IMT；bloodlipidsandrelatedmolecularindicators.Result
6、:Thepatientsintheatorvastatingroupwassignificantlylowerthancomparisonbetweenplaquediameter,plaquethickness,plaquearea,theproportionofhardplaque,IMT；TG,TC,LDL-C,BN£Hs-CRPandMCP-1levelssetinthecontrolgroup,theproportionofsoftplaqueHDL-Clevelsweresignif
7、icantlyhigher,thereisasignificantdifferencestatisticallysignificant(P<0.01).Conclusion:Atorvastatincalciumandsimvastatinhadsignificanteffectonlipidregulation,buttheeffectofatorvastatincalciumregulationwasstrongerthanthatofsimvastatin,atorvastatinc
8、alciumandsimvastatincanreducecarotidplaquediameter,plaquethickness,plaquearea,plaquearea,carotidarterythickness(IMT),lowerBNP,Hs-CRPandMCP-1,buttheeffectofatorvastatincalciuminthesameconditionisbetterthansimvastatin.[keywords]Atorvastatincalcium;simv
