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1、血清Hey、MMP—9及颈动脉IMT在冠心病诊断中的价值摘要：目的研究血清同型半胱氨酸(homocysteine,Hey)、基质金属蛋白酶-9(matrixmetalloproteinases-9,MMP-9)及颈动脉内-中膜厚度(carotidintima-mediathickness,IMT)在冠心病中的诊断价值。方法以急性冠脉综合征(ACS)40例、稳定型心绞痛组(SA)22例并行冠状动脉造影检査的患者为观察组，同时以健康者28例为对照组，测定其Hey、MMP-9浓度和颈动脉IMT厚度。结果ACS组、SA组血清Hcy、MMP-9及颈动脉IMT水平均明显高于对
2、照组，且ACS组血清Hey、醒P_9水平明显高于SA组(P〈0.05);多支病变组血淸Hey、MMP-9浓度高于单支病变组(P<0.05)；冠心病患者血清Hey、MMP-9及颈动脉IMT三者间有明显的相关性(r分別为0.351、0.573、0.612,P〈0.05)。结论冠心病患者血清Hey、MMP-9及颈动脉IMT水平明显升髙;血清Hey、MMP-9可在一定程度上反映粥样斑块的不稳定性且与冠脉病变的范W相关，联合检测三者对冠心病的诊断及治疗有着重要的意义。关键词：冠心病；同型半胱氨酸；基质金属蛋白酶_9;颈动脉内-中膜厚度TheValueofSerumHey,M
3、MP-9andCarotidArteryIMTintheDiagnosisofCoronaryHeartDiseaseYANGYi-zhoul，DUJuanl,HANZi-hua2(1.DepartmentofVIP,TheFirstPeople’sHospitalofYinchuan,Yinchuan750001，Ningxia，China；2.YinchuanCityEmergencyRescueCenter,Yinchuan750001,Ningxia,China)Abstract：ObjectiveTostudythevalueoftheserumhomo
4、cysteine(homocysteine,Hey),matrixmetalloproteinase-9(matrixmetalloprotcinascs-9,MMP-9)andcarotidartery-mediathickness(carotidtheintima-mediathickness,IMT)inthediagnosisofcoronaryheartdisease.MethodsTochoose40casesofacutecoronarysyndromepatients(ACS),22casesofstableangina(SA)astheobser
5、vationgroup,andtochoose28casesofhealthypersonsasnormalcontrolgroupduringthesameperiodandmcasurthescrumofHey，MMP-9contentandthicknessofcarotidTMT.ResultsTheserumHey,MMP-9andcarotidarteryIMTlevelsinACSgroupandSAgroupweresignificantlyhigherthanthoseincontrolgroup；Serumllcy,MMP-9levelsofA
6、CSgroupwerehigherthanthoseinSAgroup(P〈0.05);ThescrumHey,MMP-9levelofmultivcsscldiseasegroupwerehigherthanthatofsinglevesseldiseasegroup(P<0.05)；TherewasasignificantcorrelationbetweenserumHey,MMP-9levelandcarotidarteryIMTofpatientswithcoronaryheartdisease(rwere0.351,0.573，0.612，P<0.05)
7、.ConclusionTheserumHey,MMP-9andIMTlevelsarcsignificantlyelevatedincarotidartery；SerumHcy，MMP-9levelcansomeextentreflecttheatheroscleroticplaqueinstabilityandarcrelatedtocoronaryarterylesiorange,Thereisgreatsignificancetodetectthemtogetherincoronaryheartdiseasediagnosisandtreatment.Key
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