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1、Genes&SignalsThispageintentionallyleftblankGenes&SignalsMarkPtashneMemorialSloan-KetteringCancerCenterAlexanderGannColdSpringHarborLaboratoryCOLDSPRINGHARBORLABORATORYPRESSColdSpringHarbor,NewYorkGenes&SignalsAllrightsreserved©2002byColdSpringHarborL
2、aboratoryPress,ColdSpringHarbor,NewYorkPrintedintheUnitedStatesofAmericaDevelopmentalEditorSiânCurtisProjectCoordinatorJoanEbertProductionEditorDorothyBrownDesktopEditorSusanSchaeferInteriorDesignerDeniseWeissCoverDesignerEdAtkesonFrontCover(paperbac
3、kedition):“OraProNobis,”oiloncanvas(60x45inches)byHansHofmann,1964(©EstateofHansHofmann/LicensedbyVAGA,NY;courtesyAmeringerHowardYohe).(PhotobyTomPowelImaging.)LibraryofCongressCataloging-in-PublicationDataPtashne,Mark.Genesandsignals/byMarkPtashnean
4、dAlexanderGann.p.cm.Includesindex.ISBN0-87969-631-1(cloth)--ISBN0-87969-633-8(pbk.)1.Geneticregulation.I.Gann,Alexander,1962–II.Title.QH450.P832002572.8′65--dc212001053889109876543Authorizationtophotocopyitemsforinternalorpersonaluse,ortheinternalorp
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8、isitourWorldWideWebSitehttp://www.cshlpress.comForFrançoisJacobandLandLThispageintentionallyleftblankContentsPreface,xiiiForeword,xvIntroduction,1CHAPTER1■LessonsfromBacteria11RNAPOLYMERASE,11REGULATEDRECRUITMENT:THElacGENES,13Protein-DNAInteractions
