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ID:31992409
大小:1.13 MB
页数:46页
时间:2019-01-30
《木瓜中抗炎镇痛有效部位的药学.研究》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、壅丝堕型查兰曼兰兰垡丝苎一——Studiesonthepharmacyoftheeffectiveanti—inflammatoryandanalgesiccomponentfromchaenomelesspeciosaAbstractInordertoresearchtheoptimumtechnicsofproducingglycosidesofchaenomelesspeciosa(GCS)--theeffectiveanti—inflammatoryandanalgesiccomponentofchaeno
2、melesspeciosa,andtoestablishthequalitystandard,thepharmacodynamicsexperimentsofthreeextractsfromchaenomelesspeciosawerestudiedastheparameterofanti—inflammatoryandanalgesiceffect.Meanwhile,differentconditionsforextractingGCSwereanalyzedthroughtheorthogonaldesig
3、nexperimentswithanalysisofvariance,ThetechnicalconditionsandparametersofOCS’sillustrationandpurificationwithmacroporusadsorptiveresinwereinvestigated.ThequalitystandardsofGCSwereestabljshedTocomparetheanti—inflammatoryandanalgesiceffectsofthetotalextractsofcha
4、enomelesspeciosa(TECS),GCSandnon—glycosidesofchenomelesspeciosafNGCS),theearswellinginmicewithxylenewasused.Theanti—inflammatoryeffectsofthreeextractsfromchaenomelesspeciosawereobserved.hot-platetestwasusedtoassesspainthresholdinmice,andobservedtheanalgesiceff
5、ectsofthreeextractsfromchaenomelesspeciosa.GCS60,120,240mg.kg一1igsignificantlyinhibitedtheacuteimflammationinducedbyxylene,anddemonstratedthedose—relatedinhibitoryeffect,NGCS200,400rag.kg—hadrioinhibitoryeffect.WhenGCS120,240mg.kg一1administeredintragastrically
6、,thepainthresholdwasrisenremarkablyinmice,andtheanalgesiceffectwasdependentonthedosage.GCShadtheeffectofanti—inflammationandanalgesia.OCSistheeffectivecomponentofanti-inflammationandanalgesiafromchaenomelesspeciosa.4窒堂堕型查堂堕主兰垡堡苎一一Theoptimumpreparationprocessof
7、GCSwasinvestigatedbytheorthogonaldesignastheGCScontentindex,whichwasdeterminedbycolormetricmethodTheoptimumalcohol—extractingfactorswere8timesof80%alcohol,refiuxingandextractingforlh,for3times.ThetechnicalparametersofGCS’Spurificationwithmacroporousadsorptiver
8、esinwereinvestigated,andthequalitycontrolsystemwasestablished.ThistechniquewasagoodmethodtopurifyGCS.Thewatersolutionoftheoptimumalcohol—extractswasabsorbedforlhwithacolumnofmacrop
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