利多卡因微乳凝胶外用制剂的制备与药效学评价

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1、万方数据浙江大学硕士学位论文lidocaineisthepreparationoftransdermaldrugdeliveryformulationssuitable．2．Theoptimumformulationoflidocainemicroemulsion：lidocainecontentis2％，ethyloleatewas4％，Twain-80Was15％，for9％ofanhydrousethanol，deionizedwateriS70％．Invitrooptimalformula

2、tionoflidocainemicroemulsionreleasingperformanceisgood，thesizeofmicroemulsionareabout40nto，transmissionelectronmicroscopyshowedsphericaldroplets，stabilitystudyshowedthemicroemulsionpreparationwasstable．3．ThroughscreeningtodeterminethegelmatrixforCarbo

3、pol940，theoptimalprescriptionoflidocainemicroemulsiongel：Carbopol940wasO．5％，thecontentoflidocaine2％，ethyloleatewas4％，Twain-80was15％，for9％ofanhydrousethanol，deionizedwateris69．5％．Optimalmicroemulsiongelformulationofpreparationsinvitroreleasebehaviornea

4、rzeroorderrelease，physicochemicalpropertiesandstabilityofthepreliminaryinvestigationresultsshowthatthephysicalandchemicalpropertiesandstabilityofthepreparationweregood．4．Theanalgesicexperimentsshowthat，inlow,highdose，themicroemulsiongelCandosedependen

5、tlyincreasedthepainthresholdofmice，andinthesamedosage，microemulsiongel，highdosesof45minand60minintheblankcontrolgroup，with2％lidocainegelgroup，solutionof2％lidocainegroupwerestatisticallysignificant(P<0．05)，theseresultssuggestthattheanalgesiceffectofmic

6、roemulsiongel，highdosethangelgood．Theskinirritationtestresultsshowthat，thehighdoseofmicroemulsionwithmildirritationtonormalintactskin，microemulsiongelhighdosetonormalintactskinwithoutirritation，butmicroemulsionandmicroemulsiongel、析tllhighdosetothebrok

7、enskinwithmildstimulation，suggestingthatlidocainemicroemulsiongelhasgoodsafety．Conclution：Lidocainemicroemulsiongelhastheadvantagesofsimplepreparationprocess，easycoating，smallparticlesizeanduniformdistributionoflocalanesthesia,showedbetteranalgesiceff

8、ectandgoodsafety,developingitasalocaltransdermaldrugdeliverysystemhascertainvalueinclinicalapplication．Keywords：Lidocaine；microemulsion；gel；pseudo—temaryphasediagram；transdermaldelivery；AnalgesiaV万方数据浙江大学硕士学位论文缩写、符号清单、术语表VI万方数据浙江大学硕士学位论文目录目录致谢