循环肾素--血管紧张素--醛固酮系统与2型糖尿病证型相关性的分析

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1、AbstractObjective：ToinvestigatetherelationshipofserumangiotensinII(AngII)andaldosterone(ALD)withglycosylatedhemoglobin(HbAlc)，ageandtheotherbiochemicalindexinpatients谢tll够pe2diabetes．Alsowediscussesthecorelationbetweenrenin-angiotensin·aldosteronesystem(RAAS)anddiabeticperipheralne

2、uropathy．Inaddition，weobservetherelationshipbetweenRAASandyindeficiencyandheatsyndrome，phlegm-dampnesssyndrome，bloodstasissyndromewithType2diabetespatients。ThisstudyCallprovidecertainobjectivereferencebasisforthestudyofTCMsyndromeoftype2diabetes．Methods：Sixty—threepatientwithtype2d

3、iabetesrecivedmeasurementsofAnglI，AL2D，HOMA-IR，fastingbloodglucose(FBG)，fastinginsulin，HbA1c，homeostasismodelofassessmentforinsulinresistenceindex(HOMA—IR)，triglyceride(TG)，totalcholesterol(TC)，lowdensitylipoproteincholesterol(LDL—c)，ALDandAnglI．Thenallpatientswererespectivelydivid

4、edintotwogroups：hypertensiongroup(n=21)andnon-hypertensiongroup(n=42)，high-HbA1C(h-HbAlc)group(n=33)andnon—high—HbAlc(non—h—HbAlc)group(n=30)，elderlygroup(n=33)andnon—elderlygroup(n=30)，diabeticperipheralneuropathy(DPN)groupandnon—DPNgroup．Allthepatientsdiabetesdialecticalpointstyp

5、e：yindeficiencyandheatsyndromegroup(n=27)andnon-yindeficiencyandheatsyndromegroup(n=36)，phlegm-dampnesssyndromegroup(n=34)andnon—phlegm—dampnesssyndromegroup(n=29)，bloodstasissyndromegroup(n218)andnon—bloodstasissyndromegroup(n=45)．Therelationshipamongthebiochemicalindexwasanalyzed

6、．Results：TherewasapositivecorrelationofthelevelsoftheALD，Ang11withHbAlc．Otherwise。ThelevelsofALDandAng11werenegativelycorrelatedwithageinpatients、舫t}Itype2diabetes．ThelevelofAng11waspositivelycorrelatedwithFBGALDandAngIIinhypertensiongroupandnon—hypertensiongroupwasnotsignificantly

7、different．．However,FBG,HOMA—IR，ALD，AngIIinh-HbAlcgroupweresignificantlyhigherthaninnon-h—HbAlcgroup．Low-densitylipoproteinCholesterol(LDL—C)、ALDandAngIIinelderlygroupwerelowerthaninnon—elderlygroup．MultipleregressionanalysisshowedthatAng11wasstillinasignificantlypositivecorrelation

8、withHbAlc，andALDwasinasign