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ID:32242831
大小:2.50 MB
页数:47页
时间:2019-02-02
《鞍膈硬脑膜取检对垂体腺瘤侵袭性诊断的意义》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、摘要目的:通过研究垂体腺瘤鞍膈硬脑膜的侵袭性,旨在为侵袭性垂体腺瘤的诊断和治疗提供理论依据。方法:对22例垂体腺瘤根据术前放射影像学分为侵袭性和非侵袭性两组:13例为侵袭性,9例为非侵袭性。开颅手术中行鞍膈硬脑膜的取检,并分别在光镜,电镜下观察鞍膈硬脑膜与腺瘤细胞之间是否浸润性生长及其生长方式的差异性。并应用MaxVisonTM免疫组化方法分别检测两组病人垂体腺瘤石蜡切片中MMP--2、MMP一3、MMP一9的表达。统计分析光镜、电镜下观察的鞍膈硬脑膜与腺瘤细胞之间的关系及MMP一2、MMP--3、MMP
2、一9的表达在两组病例中的差异,及差异大小。进一步探讨分析它们与垂体腺瘤侵袭性的关系。结果:l、光镜下侵袭性垂体腺瘤组的鞍膈硬脑膜腺瘤细胞浸润率(84.6%.)明显高于非侵袭性垂体腺瘤组(33.3%),经统计学分析PO.05,差异无显著性意义。3、MMP.2、MMP.3、MMP.9在侵袭性垂体腺瘤组的阳性表达率分别为76.9%、61.5%、92.3%,明显高于
3、非侵袭性垂体腺瘤组的22.2%、11.1%、33.3%,经统计学分析均P4、腺瘤侵袭性的参考指标。关键词:垂体腺瘤;侵袭性;鞍膈:电镜;光镜;基质金属蛋白酶Abstract——————————————————————————————————————————————————————一一一一ABSTRACTobjective:Tostudyinvasivenessofpituitaryadenomatodiaphragmasellaedura,toprovidehelpforthediagnosisandtreatmentofinvasivepituitaryadenoma.Meth5、ods:22casesofdiaphragmasellaedurawerebiopsiedduringtranscranialpituitaryadenomaoperation.Allspecimensweredividedintoinvasivegroup(13cases)andnon-invasivegroup(9cases)ontheirradiationimagingproperties.Pathologicalobservationsoftumorcellforitsinvasionandgro6、wthpatternvariabilitvinthedurawereconductedthroughlightmicroscopeandelectronmicroscope.ExpressionofMMP一2、MMP一3、MMP一9in22slicesofspecimenswereexaminedbyMaxVisonTMimmunohistochemistrymethod.Finallyweanalyzeda11observationresultstosearchsignificantrelationsh7、ipinthepituitaryadenomainvasiveness.Results:1、Throughlightmicroscope,thediaphragmasellaeduratumorcellinfiltrationrateininvasivepituitaryadenomasgroupandinnon.invasivepituitaryadenomasgroupare84.6%and33.3%respectively.thedifferencebetweentwogroupsissignifi8、cantenoughtobeofstatisticalvalue(P<0.05).2、Throughelectronmicroscope,thediaphragmasellaeduratumorcellinfiltrationrateininvasivepituitaryadenomasgroupandinnon.invasivepituitaryadenomasgroupare85.7%and60.0%respectivel
4、腺瘤侵袭性的参考指标。关键词:垂体腺瘤;侵袭性;鞍膈:电镜;光镜;基质金属蛋白酶Abstract——————————————————————————————————————————————————————一一一一ABSTRACTobjective:Tostudyinvasivenessofpituitaryadenomatodiaphragmasellaedura,toprovidehelpforthediagnosisandtreatmentofinvasivepituitaryadenoma.Meth
5、ods:22casesofdiaphragmasellaedurawerebiopsiedduringtranscranialpituitaryadenomaoperation.Allspecimensweredividedintoinvasivegroup(13cases)andnon-invasivegroup(9cases)ontheirradiationimagingproperties.Pathologicalobservationsoftumorcellforitsinvasionandgro
6、wthpatternvariabilitvinthedurawereconductedthroughlightmicroscopeandelectronmicroscope.ExpressionofMMP一2、MMP一3、MMP一9in22slicesofspecimenswereexaminedbyMaxVisonTMimmunohistochemistrymethod.Finallyweanalyzeda11observationresultstosearchsignificantrelationsh
7、ipinthepituitaryadenomainvasiveness.Results:1、Throughlightmicroscope,thediaphragmasellaeduratumorcellinfiltrationrateininvasivepituitaryadenomasgroupandinnon.invasivepituitaryadenomasgroupare84.6%and33.3%respectively.thedifferencebetweentwogroupsissignifi
8、cantenoughtobeofstatisticalvalue(P<0.05).2、Throughelectronmicroscope,thediaphragmasellaeduratumorcellinfiltrationrateininvasivepituitaryadenomasgroupandinnon.invasivepituitaryadenomasgroupare85.7%and60.0%respectivel
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