tnf信号通路图生物帮

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1、TNF信号通路图日期：2012-04-16  来源：未知标签： 肿瘤坏死因子 信号 TNF acts several 通路摘要: TNF信号通路图天隆科技NP968自动核酸提取仪，产品试用进行中！佛山泰尔健生物细胞培养器材诚征代理TNFactsonseveraldifferentsignalingpathwaysthroughtwocellsurfacereceptors,TNFR1andTNFR2(SeeTNFR1andTNFR2SignalingPathways)toregulateapoptoticpathway

2、s,NF-kBactivationofinflammation,andactivatestress-activatedproteinkinases(SAPKs).InteractionofTNFR1withTRADDleadstoactivationofNF-kBandapoptosispathways,whileinteractionwithTRAF2has GENErallybeenthoughttobeinvolvedinstresskinaseandNF-kBactivationbutisnotrequired

3、forTNFtoinduceapoptosis.ActivationofNF-kBismediatedbyTRAF2throughtheNIKkinaseandalsobyRIPbuttheobservationthatTNFactivatesNF-kBinmicelackingTRAF2indicatesthatTRAF-2doesnotplayanessentialroleinthisprocess.Stress-activatedproteinkinases,alsocalledJNKs,areafamilyof

4、mapkinasesactivatedbycellularstressandinflammatorysignals.BindingofTNFtotheTNFR1receptoractivatesthegerminalcenterkinase(GCK)throughtheTNFadaptorTraf2,activatingthemapkinaseMEKK1.BothGCKandMEKK1interactwithTraf2,andGCKisrequiredforMEKK1activationbyTNF,butGCKkina

5、seactivitydoesnotappeartoberequiredforMEKK1activation.Instead,GCKactivatesMEKK1bycausingMEKK1 oligomerizationandautophosphorylation.TankincreasestheaffinityofTraf2forGCKtoincreaseMapkinaseactivationbyTNF.Onceactivated,MEKK1standsatthetopofamapkinasepathwaysleadi

6、ngtotranscriptionalregulation,includingJNKphosphorylationofc-JuntostimulatetranscriptionalactivationbyAP-1,aheterodimerofc-junandfosorATFproteins.Theactivationofthep38MapkinasealsocontributestoAP-1activationleadingtothetranscriptionalactivationofmanystressand gr

7、owthrelatedgenes.RIPhasbeensuggestedasacomponentofthep38pathwayinadditiontoplayingarolein nf-kbactivation.MEKK1knockoutmicesupporttheroleofMEKK1inJNKactivationinsomecellsbutdidnotsupportMEKK1dependentactivationofNF-kB.Alternativeredundantmechanismsmayobscurether

8、oleofMEKK1inNF-kBmechanisms.TNFactivationofstresskinasepathwaysanddownstreamtranscriptionfactorsmayhelptomodulatetheapoptoticpathwaysalsoactivatedbyTNF.Contributor:RE