福建省女性乳腺癌危险因素的单中心病例对照研究

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1、分类号：R73学校代码：10392学科专业代码：100214学号：1210305109福建医科大学硕士研究生毕业论文福建省女性乳腺癌危险因素的单中心病例对照研究SingleCentreCase-ControlStudyonbreastcancerriskfactorsinFujianProvince学位类型：临床医学硕士所在学院：协和临床医学院研究生：张敏艳学科、专业：肿瘤学导师：王川教授研究起止日期：2010年9月至2012年4月答辩日期：2012年05月28日二○一二年六月1万方数据2万方数据目录一、中文摘要···········

2、···········································（4）二、英文摘要······················································（5）三、英文缩略词对照表···········································（6）四、正文····························································（7）前言····································

3、··························（7）1、材料和方法·················································（8）2、结果························································（10）3、讨论························································（18）4、结论··················································

4、······（23）5、参考文献···················································（24）五、致谢···························································（28）六、综述···························································（29）3万方数据福建省女性乳腺癌危险因素的单中心病例对照研究中文摘要目的：通过流行病学调查分析，探讨影响福建女性乳腺癌发生的相关危险因素

5、，为乳腺癌的预防提供一定的参考依据。方法：本研究采用单中心病例对照研究方法，研究对象来源于福建医科大学附属协和医院乳腺外科和体检中心，包括病例组975例及对照组1091例。通过问卷调查，收集乳腺癌患者及健康体检者的相关危险因素情况，应用SPSS17.0统计软件进行乳腺癌相关危险因素的单因素和多因素非条件Logistic回归分析。结果：单因素分析和多因素分析结果显示：初潮年龄≤12岁（OR=1.619，95％CI：1.073～2.444)、乳腺癌家族史(OR=2.357，95％CI：1.535～3.621)、饮酒史(OR=6.376，9

6、5％CI：1.781～22.822)为福建女性乳腺癌的危险因素。结论：初潮年龄早（≤12岁）、家族史、饮酒史为福建女性乳腺癌的危险因素。关键词：乳腺癌；危险因素；病例对照研究4万方数据SingleCentreCase-ControlStudyonbreastcancerriskfactorsinFujianProvinceAbstractObjectiveASingleCentre-CaseControlStudywasconductedtoexploreriskfactorsoffemalebreastcancerinFujianP

7、rovince.MethodsASingleCentre-CaseControlstudyon975breastcancerpatientsand1091controlswasconductedinFujianMedicalUniversityUnionHospital．ConditionalUnivariateandmultivariatelogisticregressionwasappliedtoanalyzetheassociationbetweenriskfactorsandbreastcancer．ResultsUnivar

8、iateandmultivariatelogisticregressionanalysisindicatedthatageofmenarche≤12（OR=1.619，95％CI：1.073～2.444)、familyh