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1、胱抑素C测定在肾功能不全中的临床应用张兴宗林云张红文文晓燕(云南省中医医院检验科云南昆明650021)【中图分类号】R446【文献标识码】A【文章编号】1672-5085(2012)9-0063-02【摘要】目的探讨肾功能损害时血清胱抑素C(CystatinC,CysC)作为早期敏感标志物对临床诊断的价值。方法釆用胶乳增强透射比浊法测定血清CysC的浓度，同时测定血肌肝(Scr)、尿素(BUN)与肾小球滤过率(GFR)进行比较。结果血清CysC在健康对照组、肾功能不全代偿期组、肾功能不全失代偿期组、肾衰渴组、尿毒症期组测定值分别为(0.83±0.2
2、8)>(1.44±0.33).(2.31±0.61)>(5.09±1.68)>(7.93±1.25)mg/L,随着肾功能的损害程度增加，血清CysC的浓度升高,相邻各组之间CysC差异均有统计学意义(P<0.01)o肾功能不全代偿期组血清CysC值与健康对照组相比差异有统计学意义(P<0.05),而两组Scr、NUB相比差异无统计学意义(P>0.05)。结论肾功能不全不同损害期血清CysC浓度与肾功能损害程度相关，血清CysC作为反映肾脏损伤的敏感指标，在肾功能损害早期优于Scr、BUN,
3、CysC与其他肾功能指标联合检测对正确评估肾功能损害程度有重要临床价值。【关键词】胱抑素C肾功能损害肾小球滤过率肾衰竭ClinicalchemistrypharmacologicalbasisarenotsatisfiedwiththeresultoftheimportaneeoftheprojectanalysisZhangXing-zong,LinYun,ZhangHong-wen,WenXiao-yanDepartmentofClinicalLaboratory,YunnanProvincialHospitalofTraditionalChineseMed
4、icine,KunmingYunnan650021,China.[Abstract]ObjectiveExplorewhenrenalimpairmentinseruminhibitionchangeC(CystatinC,CysC)asearlysensitivemarkerofclinicaldiagnosisofvalue.MethodsThelatexstrengthentransmissionmethodtodeterminetheturbiditythantheconcentrationoftheserumCysC,atthesametimetest
5、ing(Scrj,serumcreatinineurea(BUN)andestimatedglomerularfiltrationrate(GFR)arecompared.ResultsSerumCysCinhealthcontrol,renalinsufficiencyofcompensatorygroup,renalinsufficiencydecompensatedperiodgroup,kidneyfailuregroup,uremia,respectively,indeterminationofgroup(0.83+/-0.28),(1.44+/-0.
6、33),(2.31+/-0.61),(5.09+/-l.68),(7.93+/-l.25)mg/L,withrenaldamagedegreeincrease，theconcentrationoftheserumCysCincreases,adjacentCysCdifferencesbetweengroupsarestatisticallysign讦icant(P<0.01).RenalinsufficiencyofserumCysCcompensatorygroupvalueandhealtharestatisticallysignificantdif
7、fereneeinthecontrolgroup(P<0.05),andtwogroupsofScr,NUBdiffereneeinwasnotstatisticallysignificant(P>0.05)•ConclusionRenalinsufficiencyofdifferentdamageserumCysCconcentrationandkidneydamagerelated,serumCysCasreflectkidneydamagesensitiveindex,inearlyrenalimpairmentisbetterthantheS
8、cr,BUN,CysCa
