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ID:33005861
大小:1.68 MB
页数:38页
时间:2019-02-19
《自体富含血小板血浆回注对兔关节软骨影响的实验分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中文摘要2染色2.1HE染色正常关节软骨表面光滑,软骨细胞分布均匀,无簇聚软骨细胞,潮线清晰完整。实验组软骨表面不光滑,可见细小碎屑。细胞排列欠整齐,细胞分裂相增多,可见软骨细胞簇聚,潮线变模糊。2.2AlcianBlue染色正常关节软骨软骨细胞周围的酸性黏多糖呈深蓝色,基质部分呈淡蓝色;实验组术后第1周软骨细胞周围颜色减退最明显,第3周渐好转,第5周恢复接近正常深蓝色。2.3过碘酸雪夫氏反应(PAS)染色正常关节软骨中软骨组织基质中的中性黏多糖呈紫红色,而软骨细胞内为无色.实验组术后第1周软骨组织基质颜色减退最明显,第3周渐好转,
2、第5周恢复接近正常紫红色。3含水率的改变实验组在第l周关节软骨的含水率(80.67+4.88)%与空白对照组(65.86+3.60)%比较差异显著(PO.05);实验组的含水率在第l、3、5周的比较均差异显著(PO.0
3、5)。4胶原含量中羟脯氨酸含量的改变实验组在第l周关节软骨中羟脯氨酸的含量(51.6+3.1)mg/L与空白对照组(62.8-4-2.5)mg/L比较差异显著(PO.05)。实验组在第5周关节软骨中羟脯氨酸的含量(63.8土3.1)mg/L与空白对照组(63.4士3.O)mg/L比较无差异(P>O.05)。实验组胶原含量中羟脯氨酸含量在第l周与3、5周比较差异显著(P4、异(P>O.05)。空白对照组胶原含量中羟脯氨酸含量在第l、3、5周的比较均无差异(P>O.05)。中文摘要5兔血清中MMP.3与TIMP.1含量的改变5.1兔血清中MMP.3含量的改变实验组血清中的MMP.3含量在第1周(7.6士0.6)ug/L与第3周(10.5+1.7)ug/L比较差异显著(PO.05)。5.2兔血清中TIMP.1含量的改变实验组血清中的TIMP.1含量在第1周(3.8+0.7)ug/L与第3周5、(20.4+3.O)ug/L比较差异显著(P6、splatelet-richplasma··induceddamagetorabbitarticularcartilageABSTRACTobjeetive:Withthesocio—economicdevelopmentandtheprocessofagingpopulationaccelerating,thenumberofthepatientswhosufferedfromhigh-energytraumaandosteoarthritisincreasing,articularcartilageinjuryandrepair7、hasbecometroubledbythebasicresearchandclinicalorthopedictreatmentofdifficultissues.Therefore,thesystemicapproachofarticularcartilageinjuryandrepairisofgreatsignificance.Thearticularcartilagedamageandjointbleedinghavesomecloseties,existingresearchshowsthat:wholebloodors8、omeofitscomponentsonlycontactwithchondrocytesincartilagecellsinafewhourswouldalsocauseveryseriousdamage.Inaddition,so
4、异(P>O.05)。空白对照组胶原含量中羟脯氨酸含量在第l、3、5周的比较均无差异(P>O.05)。中文摘要5兔血清中MMP.3与TIMP.1含量的改变5.1兔血清中MMP.3含量的改变实验组血清中的MMP.3含量在第1周(7.6士0.6)ug/L与第3周(10.5+1.7)ug/L比较差异显著(PO.05)。5.2兔血清中TIMP.1含量的改变实验组血清中的TIMP.1含量在第1周(3.8+0.7)ug/L与第3周
5、(20.4+3.O)ug/L比较差异显著(P6、splatelet-richplasma··induceddamagetorabbitarticularcartilageABSTRACTobjeetive:Withthesocio—economicdevelopmentandtheprocessofagingpopulationaccelerating,thenumberofthepatientswhosufferedfromhigh-energytraumaandosteoarthritisincreasing,articularcartilageinjuryandrepair7、hasbecometroubledbythebasicresearchandclinicalorthopedictreatmentofdifficultissues.Therefore,thesystemicapproachofarticularcartilageinjuryandrepairisofgreatsignificance.Thearticularcartilagedamageandjointbleedinghavesomecloseties,existingresearchshowsthat:wholebloodors8、omeofitscomponentsonlycontactwithchondrocytesincartilagecellsinafewhourswouldalsocauseveryseriousdamage.Inaddition,so
6、splatelet-richplasma··induceddamagetorabbitarticularcartilageABSTRACTobjeetive:Withthesocio—economicdevelopmentandtheprocessofagingpopulationaccelerating,thenumberofthepatientswhosufferedfromhigh-energytraumaandosteoarthritisincreasing,articularcartilageinjuryandrepair
7、hasbecometroubledbythebasicresearchandclinicalorthopedictreatmentofdifficultissues.Therefore,thesystemicapproachofarticularcartilageinjuryandrepairisofgreatsignificance.Thearticularcartilagedamageandjointbleedinghavesomecloseties,existingresearchshowsthat:wholebloodors
8、omeofitscomponentsonlycontactwithchondrocytesincartilagecellsinafewhourswouldalsocauseveryseriousdamage.Inaddition,so
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