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1、HazardousSubstancesDataBank,NationalLibraryofMedicine,Bethesda,MD.http://toxnet.nlm.nih.gov/DownloadedSeptember,2004THIOPHANATEMETHYLCASRN:23564-05-8Forotherdata,clickontheTableofContentsHumanHealthEffects:HumanToxicityExcerpts:Amongmenwhotreatedcitruswith
2、thiophanate-methylaswellasemulsifiedsulfurandcalciumpolysulfideinKumamotoPrefecture,theincidenceofdermatitiswas30.3,48.2,and52.8%in1972,1973,and1974,respectively.Thecorrespondingvaluesforwomenwere32.3,56.3,and64.8%.Theareasaffectedweretheabdomen,back,andwa
3、ist.Symptomsincludeditching,redness,swelling,dryness,andsometimessensitizeddermatitis.Symptomsfrequentlyappeared1wkafterexposure.Theocularmucosawascongested.Theincidenceofpositivepatchtestswasonlyabout5%.Medicalexamrevealedsomeabnormalitiesofhemoglobin.[Ha
4、yes,W.J.,Jr.,E.R.Laws,Jr.,(eds.).HandbookofPesticideToxicology.Volume3.ClassesofPesticides.NewYork,NY:AcademicPress,Inc.,1991.1458]**PEERREVIEWED**Skin,EyeandRespiratoryIrritations:Mildskin&eyeirritant.[Tomlin,C.D.S.(ed.).ThePesticideManual-WorldCompendium
5、.10thed.Surrey,UK:TheBritishCropProtectionCouncil,1994.988]**PEERREVIEWED**ProbableRoutesofHumanExposure:Occupationalexposuretothiophanate-methylmayoccurthroughinhalationanddermalcontactwiththiscompoundatworkplaceswherethiophanate-methylisproducedorused(SR
6、C).Workerre-entryexposuretopesticidesresiduesingreenhousesisaprobableexposureroutebaseduponastudyinwhichthiophanate-methylwasappliedtocarnationsviahigh-volumesprayingatapplicationratesof150and325gai/1000sqm,showinghalf-livesof22and41days,respectively(1).De
7、rmalexposureofgreenhouseworkerstothiophanate-methyl(appliedbyspraying)oncarnationsculturedingreenhouseswasfoundtobe64mg/day(duringcuttingoperations)and23mg/day(duringsortingandbundling)(2).[(1)BrouwerDHetal;BullEnvironContamToxicol58:976-84(1997)(2)VanHemm
8、enJJetal;MedFacLandbouwwUnivGent57/3b:1271-1283(1992)]**PEERREVIEWED**EmergencyMedicalTreatment:AnimalToxicityStudies:Non-HumanToxicityExcerpts:FlowcytometrictechniquewasusedtostudytheeffectsofthefungicideThi