卡托普利、心复康口服液对慢性心衰大鼠心肌线粒体呼吸酶复合物活性的影响

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1、英文摘要Effectsofcaptopril、XinFuKangOralLiquidontheactivitiesofcomplexesI-Ⅳintherespiratoryn‘一^一‘‘■_‘■．chainofmyocardiummttocondrtaInChronicHeartFailureRatsABSTRACTobjective：ThepaperfocusesontheeffectoftraditionalChinesemedicineXinFuKangOralLiquidoncardiacfunctionandtheactivitiesofcomple

2、xesI一Ⅳintherespiratorychainofmyocardiummitochondriainpressureoverload．inducedleftventricularhypertrophyinducedbyabdominalaorticconstrictioninrats．AlsoitdiscussesthemechanismoftheenergymetabIolisminCHFaswell雒thetreatmentofCHF．，．Methods：randomallocationWaStakentoaveragelydivide100SDrat

3、sintofourgroups：Shamoperation(SH)，Coarctationofabdominalaortamodelgroup(CAA)，CaptoprilTabletscuregroup(CAP)andXinFuKangOralLiquidgroup(XFK)·Pressureoverload—inducedleftventricularhypertrophyinducedbyabdominalaorticconstrictionwasusedtoprepareratmodelswithcongestiveheartfailure．Andthe

4、nmeasuretheparametersofcardiacfunction．TheactivitiesofcomplexesI．ⅣintherespiratorychainofmyocardiummitochondriaweremeasuredbyShanghaiGENMEDCO，LTD．一supplied4荚文摘要——————————————————————————————————————一一lassaykitforthe．purposeofobservingtheindexoftheparametersofcardiacfunction(氓SAP,DAP,

5、舢，LVEDP,士dp／dtmaxetc．)andthechangeofactivitiesofcomplexesI—IVintherespiratorychain(NADHreducase，SDH，Co．Qnz2Cyt．Creducase，cco)aftersixandeightweeksrespectively．Result：(1)Thestudyfunctiondecreased，LVMI、showsthatCAAgroupcardiacSAP、DAP、LVEDPincreased，+dp／dtmax，-dp／dtmaxdecreased，andtheac

6、tivitiesofcomplexesI—IVdecreased，amongwhichthedecreaseofSDHandCCOhassignificantmeaning(P

7、ous(P

8、iacfunctionp