电针水沟对脑缺血大鼠降钙素基因相关肽与神经肽y影响的实验分析

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1、湖北中医学院2007届硕士研究生毕业论文ABSTRACTobiective：Cerebrovasculardiseaseisacommonandfrequentlyoccurringillness，diseasewiththefeau鹏ofhighdiseaseincidence，highmortalityrateandhighmutilationrote．Agreatdealofclinicalresearchesandempiricalstudiesshowthatacupuncturehasuniquecurativeeffectont

2、hisdisease．Toapproachits’mechanismofaction,wecarriedoutthisexperiment．TheSDratswereobjectsinthisexperiment．Wemaderatfocalcerebralischemiamodelwithmiddlecerebralarteryocclusionusingathreadblocktechnique．Wegaveamarkoftheneurologicimpairmentinratanddetectedthecontentsofcalcite

3、ningene-relatedpeptide(CGRP)andneuropeptideY(NAY)inmrs’cA)innammonisandbrainmantlerespectivelybyelectro-acupuncmre(EA)onshuigou(DU26)acupoint．Inthisway,wearetryingtoexplorethemechanismofacupuncturetherapyincerebralischcmia．Methods：40SDratswereselected．Eachrat’Sweightwasfrom

4、1809to2409．Theywererandomlydividedintofourgroups,eachgroupwith10mrs：normalgroup，shamoperationgroup，modelgroupandmodelEAgroup．Normalgroupmtswerenotprovidedtreatment．Modelgroupwerelnadefocalcerebralischemiamodelwithmiddlecerebralarteryocclusionusingathreadblocktechnique．Model

5、EAgroupwastreatedbyEAwithcontinuouswaveof120vicesperminutefrequencyaftertheratswokeup．Thetreatmentcontinuedforfivedays，onevicefor30minutesperday．Then,wemarkedoftheneurologicimpairmentintheratsanddetectedthecontentsofCGRPandNPYinthemrs’cornuammonisandbrainmantlerespectively．

6、Results：1．focalcerebralischemiarats诵thrightmiddlecerebralarteryocclusionusingathreadblocktechniquehadbehaviordisordertosomedegree，withlevo-circlingobjectivesigns，andtheirleftforefootflectioncouldn’texpandthoroughly．ThisshowedthattheCImodelssucceeded．AftertreatedbyEA,neurolo

7、giedefectobjectivesignsofratimprovedobviously．Comparedwithmodelgroup，therewassignificantdifference伊

8、dthatthecontentsofCGRPandNPYin3湖北中医学院2007届硕L研究生毕业论文gOmUammonisaeTahadabnormalityva