电针对兔膝骨关节炎软骨中β-catenin表达的影响

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1、Electro-acupuncturetherapyonrabbitkneeosteoarthritisp-cateninexpressioninthecartilageAbstract：Objective：osteoarthritis(OA)isamultiplediseaseintheelderly,it’Spathologicalexchangeincludesarticularcartilagedegeneration，destructionandosteophytesformation．Traditionalviewist

2、hattheoverexpressionofproinflammatoryfactorsIL-1，IL-6，1M-仅andproteaseclassesMMP．1，MMP-3，M／rIP一9playimportantrolesinOA．However,relatedgeneknockoutmiceanimalexperimentsdidnotprovidestrongevidence，intheclinicaltreatment，applicationofanti-inflammatorydrugsandproteaseinhibi

3、torsdidnotachieveanidealresult．Therefore，thepathogenesisofOAneedtobefurtherclarified，inrecentyears，researchersshowedthatWnt／13一cateninsignalpathwayplaysanimportantroleinthepathogenesisofOA．Theanimalexperimentshowed：specificincreasetheexpressionof13-catenininkneejointca

4、rtilagecellsofadultmice，themicewillappearOA—likechange，whichrevealedthattlleup。regulationofWnt／13-cateninsignalingpathwayleadtotheoccurrenceofOA．OAtreatmentcanbedividedintooperationtherapyandnonoperationtreatment，theelectro—acupuncturetherapyisclinicallyusedasanonopera

5、tiontreatment．Thetraditionalacupunctureandelectricalstimulationarecombinedinelectro—acupuncture．AstheacupuncturestimulatetheacupointsofOApatients，whichleadstothereleaseofanalgesicsubstance，andelectricalstimulationcausemusclecontraction，whichimprovelocalbloodcirculation

6、，．5．theseallcanhelpdamagerepair．Therefore，thisarticletrystoexplorethemechanismofelectro-acupuncturetreatmentofrabbitkneeOAmodelthroughobservingthegrossmorphologychangesofarticularcartilage，thepathologicalchangesofcartilagecellsandtheexpressionof13-catenininthecartilage

7、cells．Methods：(1)Theobjectandinterventionmeasures：purchasing36NewZealandrabbitswithhealthexperimentfromtheanimalcenterofLuzhouMedicalCollege，randomlyselected12rabbitsasthenormalcontrolgroup，withoutanytreatment，modelgroupandEAgroupwith12ratsineachgroupaccordingtotheVide

8、manmethod，useplastercasttheirleftkneesstraightlyfor6weekstobuildOAmodel．6weeksaftermodeling，Electro—acupuncturetreatm