大疱性类天疱疮一例报道并文献复习

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1、万方数据山东大学硕士学位论文BULLOUSPEMPHIGOID：ACASEREPoRTANDAREVIEWOFTHELITERATUREobjectionPostgraduate：LinheshengSuPervisor：Prof．SunQingABSTRACTTheaimistoinvestigatetheclinicalmanifestations，auxiliaryexaminationFeaturesofbullouspemphigoid(BP)andtoimprovetheacquaintanceofthisdisease，todecrea

2、setherateofmisdlagnosisandmisseddiagnosis．MethodsWeretrospectivelyanalyzedthecliniealdataofonecasewhichisconfirmedbyDepartmentofdermatologyShandongUniversityQiluHospital，andreviewedforeignanddomesticliteratures．Andgaveasystematicexpositionoftheclinicalmanifestations，auxiliaryex

3、axninationandpathologicalfeatures，diagnosisandtreatmentofBP．ResultA56‘year-oldmanwitha2monthhistoryofsystemicerythema，blisters，itchingfor2months．Nisslsyndromewasnegative．Thebodyscatterederythema，blisters，bulloustension，partialerosion，surfacescab．RoutineanalysisofbloodshowedWBC8

4、．14x109／L，HGB1329／L，RBC4．05x1012／L．BiochemistryALT23U／L，AST16U／L，ALB31．99／L，BUN6．70mmol／L，Cr62umol／L．Biopsyshowedsubepidermalblisteringwithaprominentneutrophilicinfiltrate．Adiagnosisofbullouspemphigoidwasmade．Treatmentwithsystemiccorticosteroids，andimmunosuppressiveagentswasef话

5、ctive2万方数据山东大学硕士学位论文ConelutionsBullouspemphigoidisasubepidermalbullousskindisease．Itiscommonamongolderpeople．Itischaracterizedbytensionblistersinnormalorinflammationoftheskin，immunepathologicalexaminationattheepidermalbasementmembranewithlineardepositionofIgGandC3．Itneedsidenti

6、ficationwithpemphigus，acquiredbullousepidermalnecrolysis，dermatitisherpetiformisandbullousdiseasessuchaslupuserythematosus．Therefore，cliniciansshouldraisetheawarenessofthediseaseandensureearlydeteetion，earlydiagnosisandearlytreatment．Keywords：BP；reviewoftheliterature；clinicalma

7、nifestation；pathology；imrnunofluorescence万方数据山东大学硕士学位论文缩写词英文名称缩略语表BPBullouspemphigoid中文名称大疱性类天疱疮DIFDirectimmunofluorescenee直接免疫荧光检查IIFIndireetimmunofluorescenee间接免疫荧光检查4万方数据山东大学硕士学位论文．▲上．-JL刖舌大疱性类天疱疮是好发于老年人的慢性获得性自身免疫性大疱病，男女在发病比例上并无明显差异。本病表现为表皮下水疱，水疱早期较清澈，但由于发病时间的延长，疱液会变浑浊，有时可混有

8、血性，尼氏征常为阴性，常累及胸腹部、腋下、四肢屈侧、腹股沟。大疱性类天疱疮确切的发病机制目前仍不是十分清楚，