Relationship between fluoride intake in Serbian children living in two areas

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1、FoodandChemicalToxicology47(2009)1080–1084ContentslistsavailableatScienceDirectFoodandChemicalToxicologyjournalhomepage:www.elsevier.com/locate/foodchemtoxRelationshipbetweenfluorideintakeinSerbianchildrenlivingintwoareaswithdifferentnaturallevelsoffluoridesandoccurrenceofdentalfluorosisa,*bbcaZoran

2、Mandinic,MarijanaCurcic,BiljanaAntonijevic,CharlesP.Lekic,MomirCarevicaClinicofPreventiveandPediatricDentistry,SchoolofDentistry,UniversityofBelgrade,Dr.Subotica11,11000Belgrade,SerbiabInstituteofToxicology,FacultyofPharmacy,UniversityofBelgrade,VojvodeStepe450,11221Belgrade,SerbiacDepartmentofPr

3、eventiveDentalScience,FacultyofDentistry,UniversityofManitoba,780BannatyneAvenue,Winnipeg,Manitoba,CanadaR3E0W2articleinfoabstractArticlehistory:Theamountoffluoridepresentnaturallyindrinkingwaterishighlyvariable,beingdependentupontheReceived15October2008individualgeologicalenvironmentfromwhichthew

4、aterisobtained.Chronicexposuretoexceedingfluo-Accepted27January2009ridedosesinducessetoftoxiceffects,i.e.fluorosis.Theaimofthisstudywastoexaminefluoridecontentinwaterandinthemostfrequentlyusedvegetables,potatoandbean,grownintwodifferentSerbianregions,i.e.controlregion(Valjevo)andhighnaturallyoccurri

5、ngfluorideregion(VranjskaBanja),andKeywords:moreover,tocorrelateestimateddailyintakewithdentalfluorosisoccurrenceasanadverseeffectoffluo-WaterrideexposureofschoolchildreninSerbia.StudyconfirmedsignificantdifferenceinfluoridecontentinPotatowater,potatoandbean,consumedby12-year-oldchildrenintwoinvestigat

6、edmunicipalities.ResultsBeanFluorideintakeofthestudyindicatedpositiveandstatisticallysignificantcorrelationbetweendailyintakeoffluorideSchoolchildrenanddentalfluorosislevelinthefluoroticmunicipalityofVranjskaBanja(r=0.61;p=0.000017).ObtainedDentalfluorosisrelationshipcouldbeevaluatedbymeansofbinarylog

7、isticregressionanalysis,whereasprobabilityforfluorosisoccurrencecouldbepredictedusingthefollowingequation:fluorosisoccurence(%)=(34.852Cwater12.644Cpotato9.362Cbean7.673)100(Chi-Square(3)=33.033;p<0.001).Ó2009Else