hbv复制水平及基因型、亚型对hbv相关性肝病发病的影响

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1、第三军医大学硕士学位论文RoleofHBVDNAleVelandgenotype／subtypeonpathogenesisofHBV-associatedliVerdiseasesBackgroundandobjectiVeAbstractHepatitisBVirus(HBV)isamainfactorwhichcausesacuteorchronichepatitis，cirrhosis，liVerfajlureandhepatocellularcarCinoma．InChina，thereareabout23milli

2、onchronichepatitisBpatientsand130millioncarriers，aIldapproximately50percentofhepatocellularcarcinomaoccurredinChina．HepatitisBVims(HBV)hasbeenclaSsifiedintoeightgenotypeslIA-H)basedonanintergroupdiVergenceof8％ormoreinthecompletenucleotidesequence．InChina，thereaurefo

3、urgenotypes⋯一A，B，CaJldD，andthepercentageofeachofthemis1．2％，39．3％，50．2％and8．1％respectiVely．GenotypeshaVedifferentgeo铲aphicdistribution：genotypeCisprimaryfoundintheno砒ofChina(about81．6％)andinthesouthofChina，genotypeBisthemainone．TheinVest培ationofHBVsubgenotypehasbeenc

4、arriedoutinrecentyears．HuyanalyzedtheHBVsequencesofgenotypeCpatientsfromSoutheastAsiaandtheFarEastanddiVidedthemintotwosubtypes：C1(Cs)andC2(Ce)．ClsubtypeisfromSoutheastAsia，likeVietnamandThailand。C2subtypeisfromtheFarEast，likeChina，JapanaIldRepublicofKorea．GenotypeB

5、canalsobediVidedintotwosubgenotypes：Baand功．TheresearchesinandoutourcountryindicatedthatHBVgenotypepossiblycloselycorrelatewithdiseaseprOceeding，clinicalmanifestation，prognosisandantiViraltherapyresponse．ResearchersnowgenerallyconsiderthattheinflammatorynecrosisaIldf

6、ibrosisconditionsaremoreseriousinpatientswithgenotypeCthanthosewithgenotypeB，andHBeAgpositiVerateishigberinpatientswithgenotypeC；genotypeCisrelatedwithcirrhosisandhepatocellularcarcinoma；genotypeBhashigheraccumulationsurViValratethangenotypeC．Butsomestudiesinourcoun

7、tryindicatedthatthedifferencesofhepatiticfunctionallesion，inflamatorynecrosisandfibrosishaVenostatisticallysignificantbetweenthetwogenotypes．2第三军医大学硕士学位论文BasedOnthis，wechosepatientswhoinfectedwithHBVaIldwereindifferentphasesinSouthwestasobjectsforinVestigation，HBVDN

8、AleVel，HBeAg，anti—HBe，HBVgenotypesandsubtypesweremonit01．ed．Tobefirst，westudiedthedistributionoftheageandHBVDNAlevelofpatientswhosuf托redfr