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1、FeatureArticleDOI:10.1002/mabi.200600069623Summary:Alginatehydrogelsareprovingtohaveawideapplicabilityasbiomaterials.Theyhavebeenusedasscaffoldsfortissueengineering,asdeliveryvehiclesfordrugs,andasmodelextracellularmatricesforbasicbiologicalstudies.Theseapplicationsrequiret
2、ightcontrolofanumberofmaterialpropertiesincludingmechanicalstiffness,swelling,degra-dation,cellattachment,andbindingorreleaseofbioactivemolecules.Controloverthesepropertiescanbeachievedbychemicalorphysicalmodificationsofthepolysaccharideitselforthegelsformedfromalginate.Theu
3、tilityofthesemodifiedalginategelsasbiomaterialshasbeendemonstratedinanumberofinvitroandinvivostudies.Micro-CTimagesofbone-likeconstructsthatresultfromtransplantationofosteoblastsongelsthatdegradeoveratimeframeofseveralmonthsleadingtoimprovedboneformation.AlginateHydrogelsasB
4、iomaterialsAlexanderD.Augst,*HyunJoonKong,DavidJ.MooneyDivisionofEngineeringandAppliedSciences,HarvardUniversity,Cambridge,MA,USAE-mail:augst@deas.harvard.eduReceived:March22,2006;Revised:May9,2006;Accepted:May10,2006;DOI:10.1002/mabi.200600069Keywords:alginate;biopolymers;
5、drugdeliverysystems;polysaccharides;tissueengineering[5]Introduction(ligands)thatspecificallybindtocellreceptors.Inordertoachievetheseinteractions,biomaterialsareoftendecoratedThefieldofbiomedicalengineering,andbioengineeringwithaminoacidsequencestowhichspecificreceptorsoncell
6、[6]morebroadly,frequentlyrequiresmaterialswithspecificandmembranescanattach.Inaddition,bioactivemolecules[1]tunablepropertiesforawidevarietyofapplications.Insuchasgrowthfactorscanbeincorporatedandreleasedfromtissueengineering,thefocusliesontherepairandreplace-thematerial,whi
7、chcanfurtherpromoteandregulatenew[7]mentofdiseasedtissue,whichisoftenachievedbycon-tissuedevelopment.Thepossibilityofcontrolleddrugdeliv-[2]ductive,inductive,andcelltransplantationapproaches.erydirectlyfrombiomaterialsisofgreatinterest,asbolusOften,biomaterialsplaytheroleof
8、anartificialextracellularinjectionsofdrugswhicharepoorlyadsorbedwhengivenmatrix(ECM
