眼科门诊干眼的流行病学调查及相关危险因素分析

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1、眼科门诊干眼的流行病学调查及相关危险因素分析214?眼科新进展2008年3月第28卷第3期RecAdvOphthalmolVo1.28No.3March2008眼科门诊干眼的流行病学调查及相关危险因素分析张宏安晓陈雪艺Prevalenceandriskfactorsas-sociatedwithdryeyeinahos-pital-basedpopulationZHANGHong.ANXiao,CHENXue-Yl【Keywords]dryeye;epidemiologicalinvestiga-tion;riskfactor【Abstract]ObjectiveT

2、ostudytheW-d]enceofdryeyeinahospital-basedpopulationandtoevaluatetheriskfactorsattributabletodryeye.MethodsAtotalof650newoutpatientsageabove30yearswerescreenedfordryeyefromApriltoJune2005andStembertoNovember2005.Arinformedconsentwasobtainedfromsul-'ects.aquestiounJdrewerenscd,whenaresl

3、〜ondentindicatedthepresenceofsymp?tom.breakuptiIne(BUT)testwasperformed.Sub—{eetswhosethevalueofBUT<10secondswereimder—gonethedryeyetestincluding:fluoresceinstaillingtest.meibomianglandfimction.SchirmerItest,rosebangle;Thenahospitol-basedcase>controlstudywasconductedtothosesubiectsw

4、howeredeemedtobesuffering矗砌dryeye.twomatchedcontrolsperdryeyecasewererandomlyselected.Multivariatecondi一tionalLogisticregressionmodelwasusedforunivari?ableandmultivariateanalysis.ResultsSixhundredandfiftypeopleparticipated;Theyrangedinagefrom3083years(withameanof49.9years).Dryeyewaspre

5、sentin134(2O.6%)ofthestudysub.it?.iectswassigniflcantlyhi~her(P<0.001)infemales(26.2%)thaninmale(15.0%);Dry~_eyeprevalenceincreasedprogressivelywithage.itwashigherinthoseabove60yearsofagethaninyongers(P<0<05),dryeyepreva?lencemhlj瑚uminthose30years(ll.l%):Onanaly?singthepresenting

6、complaints.themostco11llTIoncomplaintwasdryne88.foundin182(28.0%)subjects,followedbyocul-fatigue158(24.3%)andthemostleastcomplaintwas0culaurpainin42(6.5%)Jn650subiectsthemeanvalueofBUTwas(9.50±2.86)sec?onds.InmalethemeanvalueofBUTwasfl0.22±2.30)seconds.whichwasstgnfficanthigherthanthat

7、infemale(8.76±3.16)seconds(P<0.001).BUrde?reasedprogressivelywithage,inthoselow60yearsof收稿日期:20074)6-22修回H期:2007—11-24木文编辑:徐刚珍作者简介:张宏，女,1969年1月出生，辽宁省瓦房店人，硕士，主治医师•联系电话:13899992735;E一mail:xjophth,,~@163.corn,MJZ.moon@yahoo.tom作者单位：830054新疆自治区乌鲁木齐市，新疆更科大学第一附属医院眼科Receiveddate:Jun22,20