内脂素、白介素-18对慢性肾脏病患者胰岛素抵抗和微炎症状态的影响

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1、英文摘要2．hourPostPrandialbloodglucose(PBG)，glycosylatedhemoglobin(HbAlc)，high—sensitivityC-reactiveProtein(hs—CRP)，serumcreatinine(Scr)，totalcholesterol(TC)，tri91ycerides(TG)，highdensityliPoProteincholesterol(HDL—C)，lowdensityliPoProteincholesterol(LDL-C)，werealldeterminedafteradmission，simultaneo

2、usdeterminedofheight，bodyweight，waistcircumference，hiPcircumferenceandcalculatebodymassindex(BMI)，waist—to-hiPratio(WHR)，glomerularfiltrationrate(GFR)，andinsulinresistanceindex(HOMA．IR)．f4)ClinicalindicatorsandexPerimentaldatawereexPressedasxis，grouPswerecomParedusinganalysisofvarianceandnon—Pa

3、rametrictest，furtherPariwisecomParisonsusingSNKanalysis．(5、)SPSS13．0statisticalsoftwarewasusedtoanalyzetheabovementioneddata．inwhichProcessthesignificancewassetat尸

4、，PatientsofCKD5washigherthanCKD1～4andPatientsCKD4washigherthan1-2(P

5、e，hs—CRP,FBGFIN，PBGHbAlc，HOMA．IR，TC，TGandLDL—C(r=0．216-0．406，P<0．05)，andnegativerelatedtoeGFRandHDL—C(严一0．370，F-0．294，P<0．05)．(3)BivariatecorrelationanalysisofIL一18andvisfatinweresignificantlyPositivecorrelation(r=0．527．P<0．01)．(4)VisfatinasthedePendentvariable，multiPlelinerregressionanalysissh

6、owedthaths．CRP,eGFRandHOMA—IRweretheindePendentrelatedfactorstovisfatin，multiPlelinerregressionequation：visfatin=6．59+0．94Xhs—CRP—O．51XeGFR+0．036XHOMA—IR(F=8．704，P<0．05)：IL．18asthedePendentvariable，multiPlelinerregressionanalysisshowedthaths—CRP’andeGFRweretheindePendentrelatedfactorstoIL一18．mu

7、ltiPlelinerregressionequation：IL一18=279．262+0．97×hs—CRP．O．63XeGFR(F=10．382．P<0．05)．Conclusions：(1)ComParedwiththenormalcontr01grouP,theextentof4英文摘要insulinresistanceandinflammatorycytokines(IL．18．hs．ERe)levelsofchronickidneydiseas