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1、中国组织工程研究与临床康复第14卷第3期2010–01–15出版JournalofClinicalRehabilitativeTissueEngineeringResearchJanuary15,2010Vol.14,No.3聚乙二醇-聚乙烯亚胺/四氧化三铁纳米磁流体的毒性及其生物相容性**★◆122222邹芬，潘一峰，张红，李国政，唐静波，彭健Toxicityandbiocompatibilityofpolyethyleneglycol-polyethyleneimine/ferroso-ferricoxidenano-magneticflu
2、id122222ZouFen,PanYi-feng,ZhangHong,LiGuo-zheng,TangJing-bo,PengJianAbstract1BACKGROUND:Polyethyleneglycol-polyethyleneimine/ferroso-ferricoxide(PEG-PEI/FeO)wasselectedasdrugcarriersinModernChinese34MedicineParkintumortreatment,whichcanincreasedrugloadingcapacityandtargeting
3、capacity.SouthChinaCo.,Ltd,OBJECTIVE:TotestthetoxicityofPEG-PEI/Fe3O4nano-magneticfluidinvitroandinvivo.Zhongshan528451,METHODS:WhenthepreparedPEG-PEI/Fe3O4nano-magneticfluidreachednanolevel,7702andHpG2celllineswerefiltratedGuangdongProvince,2China;NationalKeyanddilutedin5-2
4、0multiple,anddetectedbyinvitroMTTtoxicitytestassay;invivohemolysistestandmicronucleustestwasLaboratoryofusedtotestthetoxicityandbiocompatibility.NanobiologicalRESULTSANDCONCLUSION:MTTassayresultsindicatedthatthetoxicitygradeofPEG-PEI/Fe3O4nano-magneticfluidtoTechnology,South
5、7702celllinewas0-1,whichwasharmlesstonaturalhepaticcells;however,PEG-PEI/FeOnano-magneticfluidhadslightChinaUniversity,34Changsha410008,bystanderrestrainingeffecttoHpG2cellline.Maximumhemolysisrateofthematerialwas0.372%,whichwasfarlessthan5%.HunanProvince,Themicronucleustest
6、resultindicatedthatPEG-PEI/Fe3O4nano-magneticfluidhadnoteratogenicityormutagenicity.ChinaZouFen★,Master,ZouF,PanYF,ZhangH,LiGZ,TangJB,PengJ.Toxicityandbiocompatibilityofpolyethyleneglycol-polyethyleneimine/ModernChineseferroso-ferricoxidenano-magneticfluid.ZhongguoZuzhiGongc
7、hengYanjiuyuLinchuangKangfu.2010;14(3):447-451.MedicineParkin[http://www.crter.cnhttp://en.zglckf.com]SouthChinaCo.,Ltd,Zhongshan528451,GuangdongProvince,China摘要miffysweet@126.com背景：为实现纳米基因药物在治疗肿瘤中实现高靶向性，课题采用聚乙二醇和聚乙烯亚胺修饰的磁性四氧化三铁纳米粒(PEG-PEI/Fe3O4)作为基因药物载体，在提高载体载药能力的同时，使载体具有超顺
8、磁性，增加药物靶向性能。Correspondenceto:PengJian,Doctor,目的：评价PEG-PEI/Fe3O4纳米磁流体体外和体内毒性
