ph响应性纳米蛋白凝胶的制备及其体外释放行为的研究

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1、学校代码:10571学号:2015010122密级:公开pH响应性纳米蛋白凝胶的制备及其体外释放行为的研究StudyonsynthesisandinvitroreleasebehaviorofapH-responsiveproteinnanocapsule药学学科门类药理学学科、专业药物制剂研究方向二○一五级年级古楚莹研究生姓名李宝红研究员、刘建强副教授导师姓名2015.9～2018.5起止日期二○一八年五月目录中文摘要..................................................

2、.........1英文摘要...........................................................31前言..............................................................51.1研究背景.........................................................51.2研究目的..................................................

3、.......61.3研究内容.........................................................72材料与方法.......................................................82.1仪器与试剂......................................................82.2实验方法........................................................9

4、3结果............................................................153.1PEG-BzA的氢谱分析............................................153.2凝胶电泳结果...................................................153.3Zeta电势的测定结果.............................................163.4粒径分布......

5、.................................................173.5透视电子显微镜结果.............................................173.6体外稳定性测试.................................................183.7体外药物释放...................................................183.8细胞定性摄取....................

6、...............................193.9细胞定量摄取...................................................203.10细胞活性评价..................................................214讨论.............................................................234.1纳米蛋白凝胶的制备与表征........................

7、...............234.2nCytC-bPEG的体外稳定性与体外药物释放..........................244.3蛋白凝胶的细胞摄取.............................................254.4蛋白凝胶的细胞活性评价.........................................265小结.............................................................285.1纳米蛋白凝胶

8、的制备与表征.......................................285.2nCytC-bPEG的体外释放行为研究..................................28参考文献.........................................................