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ID:34739996
大小:4.25 MB
页数:44页
时间:2019-03-10
《趋化因子cxcl16及其受体cxcr6在子宫内膜癌组织中的表达及意义》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、趋化因子CXCLl6及其受体CXCR6在子宫内膜癌组织中的表达及意义中文摘要目的观察子宫内膜癌组织中趋化因子CXCLl6及其受体CXCR6的表达水平,探讨它们与子宫内膜癌患者临床病理特征及预后的关系,进而研究它们在子宫内膜癌发生、发展中的可能作用。方法采用组织芯片技术和免疫组织化学法检测正常子宫内膜组织、单纯性增生子宫内膜组织、不典型增生子宫内膜组织和子宫内膜癌组织中趋化因子CXCLl6及其受体CXCR6的表达,并分析CXCLl6和CXCR6在子宫内膜癌组织中的表达与患者FIGO分期、癌组织的病理分级、淋巴结转移、病理类型及年龄等临床病理因素及预后的关系。应用SPSSl7.0统计软
2、件进行数据分析,CXCLl6、CXCR6的表达分析用X2检验,子宫内膜癌中CXCLl6、CXCR6表达的相关性分析采用Spearman等级相关,子宫内膜癌患者的生存分析采用Kaplan-Meier方法及LogRank检验。以P3、高趋势,且CXCLl6及CXCR6在子宫内膜癌组织中的表达呈正相关(r=O.437,P0.05)。子宫内膜癌组织中CXCLl6的表达与子宫内膜癌患者的FIGO分期、癌组织的病理分级、淋巴结转移、病理类型及年龄均无关(P>O.05)。子宫内膜癌组织中CXCLl6的表达不影响患者的生存率(P>0.05)。CXCR6阳性表达的子宫内膜癌4、患者生存率高于CXCR6阴性表达者(P5、etrialcarcinomaAbstractObjectiveToobservetheexpressionofchemokineCXCLl6anditsexclusivereceptorCXCR6inendometrialcarcinoma,toexploretheirsignificanceinclinicalpathologicfeaturesandprognosisofendometrialcarcinoma,andtoevaluatetheirrolesintheevolutionandprogressionofhumanendometrialcarcinoma.Meth6、odsSpecimensofnormalendometrialtissue,simplehyperplasiaendometrialtissue,atypicalhyperplasiaendometrialtissueandendometrialcarcinomatissuewerecollectedandprocessedintotissuechips.TheexpressionsofCXCLl6andCXCR6inthesampleswereexaminedbyimmunohisto—chemical(IHC)staining.TherelationshipbetweenCXC7、L16andCXCR6expressionandclinicopathologicfeaturessuchasclinicalstage,pathologicgrade,lymphnodemetastasis,histologicaltype,ageandprognosisofpatientfromendometrialcarcinomawereevaluated.BytheSPSSl7.0package,theexpressionsofCXCLl6andCXCR6w
3、高趋势,且CXCLl6及CXCR6在子宫内膜癌组织中的表达呈正相关(r=O.437,P0.05)。子宫内膜癌组织中CXCLl6的表达与子宫内膜癌患者的FIGO分期、癌组织的病理分级、淋巴结转移、病理类型及年龄均无关(P>O.05)。子宫内膜癌组织中CXCLl6的表达不影响患者的生存率(P>0.05)。CXCR6阳性表达的子宫内膜癌
4、患者生存率高于CXCR6阴性表达者(P5、etrialcarcinomaAbstractObjectiveToobservetheexpressionofchemokineCXCLl6anditsexclusivereceptorCXCR6inendometrialcarcinoma,toexploretheirsignificanceinclinicalpathologicfeaturesandprognosisofendometrialcarcinoma,andtoevaluatetheirrolesintheevolutionandprogressionofhumanendometrialcarcinoma.Meth6、odsSpecimensofnormalendometrialtissue,simplehyperplasiaendometrialtissue,atypicalhyperplasiaendometrialtissueandendometrialcarcinomatissuewerecollectedandprocessedintotissuechips.TheexpressionsofCXCLl6andCXCR6inthesampleswereexaminedbyimmunohisto—chemical(IHC)staining.TherelationshipbetweenCXC7、L16andCXCR6expressionandclinicopathologicfeaturessuchasclinicalstage,pathologicgrade,lymphnodemetastasis,histologicaltype,ageandprognosisofpatientfromendometrialcarcinomawereevaluated.BytheSPSSl7.0package,theexpressionsofCXCLl6andCXCR6w
5、etrialcarcinomaAbstractObjectiveToobservetheexpressionofchemokineCXCLl6anditsexclusivereceptorCXCR6inendometrialcarcinoma,toexploretheirsignificanceinclinicalpathologicfeaturesandprognosisofendometrialcarcinoma,andtoevaluatetheirrolesintheevolutionandprogressionofhumanendometrialcarcinoma.Meth
6、odsSpecimensofnormalendometrialtissue,simplehyperplasiaendometrialtissue,atypicalhyperplasiaendometrialtissueandendometrialcarcinomatissuewerecollectedandprocessedintotissuechips.TheexpressionsofCXCLl6andCXCR6inthesampleswereexaminedbyimmunohisto—chemical(IHC)staining.TherelationshipbetweenCXC
7、L16andCXCR6expressionandclinicopathologicfeaturessuchasclinicalstage,pathologicgrade,lymphnodemetastasis,histologicaltype,ageandprognosisofpatientfromendometrialcarcinomawereevaluated.BytheSPSSl7.0package,theexpressionsofCXCLl6andCXCR6w
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