资源描述：
《3-17CACS-C-2014【3173001】-Advances in Medical Sciences-意大利-【Rev：诊治】 .pdf》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、AdvancesinMedicalSciences59(2014)1–6ContentslistsavailableatScienceDirectAdvancesinMedicalSciencesjournalhomepage:www.elsevier.com/locate/advmsReviewArticleAnorexia–cachexiasyndromeinpancreaticcancer:Recentadvancesandnewpharmacologicalapproachaaba,*IlariaRonga,FernandoGallucci,
2、FerdinandoRiccardi,GenerosoUomoaInternalMedicineUnit3,CardarelliHospital,Napoli,ItalybOncologyUnit,CardarelliHospital,Napoli,ItalyARTICLEINFOABSTRACTArticlehistory:About80%ofallpancreaticductaladenocarcinomapatientssufferfromawastingsyndromereferredtoReceived14October2013asthe‘
3、‘canceranorexia–cachexiasyndrome’’(CACS)characterizedbyabnormallylowweight,weaknessAccepted20November2013andAvailablelossofskeletalmusclemasswithorwithoutlossofbodyfat,whichdirectlyimpactsoverallsurvival,online15March2014qualityoflife,andphysicalactivity.Theaimofthisreviewwasto
4、examinerecentfindingsaboutCACS’pathophysiologyandtodescribethecurrentpharmacologicalapproaches.InrecentyearsmanyeffortsKeywords:wereAnorexiamadetoimproveourknowledgeofCACS;currentlyweknowthatcachexiaarisesfromacomplexandmultifactorialinteractionbetweenvariousmechanismsincludingi
5、nflammation,anorexia/Cachexiamalnutrition,alterationsofproteinandlipidmetabolism;consequentlyitsmanagementrequiresPancreaticadenocarcinomamultidisciplinaryandmultipharmacologicalapproachthatshouldaddressthedifferentcausesMegestrolThalidomideunderlyingthisclinicalevent.Onthesepre
6、mises,severaldrugshavebeenproposedstartingfromCorticosteroidsthefirstpharmacologicaltreatmentbasedonprogestationalagentsorcorticosteroids;mostofthemareinthepreclinicalphase,butsomehavealreadyreachedtheclinicalexperimentationstage.Inconclusion,todate,thereisnostandardeffectivetre
7、atmentandfurtherstudiesareneededtounravelthebasicmechanismsunderlyingCACSandtodevelopnewertherapeuticstrategieswiththehopetoimprovethequalityoflifeofpancreaticcancerpatients.ß2014MedicalUniversityofBialystok.PublishedbyElsevierUrban&PartnerSp.zo.o.Allrightsreserved.Contents1.In
8、troduction............................................
