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《Youyou Tu is awarded the 2011 LaskerDeBakey Clinical Medical Research Award for discovering artemisinin as a treatment for malaria .pdf》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、NewsFrombranchtobedside:YouyouTuisawardedthe2011Lasker~DeBakeyClinicalMedicalResearchAwardfordiscoveringartemisininasatreatmentformalariaTheWHOhasindicatedthatin2009,abundantrainfallaremostsuitablefordays(P.malariae).P.falciparumbecomesthemostrecentyearforwhichdataarethedeve
2、lopmentofthemalaria-carry-mostharmfulinthisstage,asinfectedavailable,approximately250millionpeo-ingAnophelesmosquitoes(5).Plasmodiumhostrbcavoidthespleenbysequester-plewereinfectedwithmalaria,andnearlyparasitesalldevelopthroughthesameingincapillariesandmicrovenulesoftheonemi
3、llionofthosepatientssuccumbedgenerallifecycle,alternatingbetweenbrainandothervitalorgans(theothertotheirinfections.ButwithoutYouyouthehumanandmosquito(Figure3).malariaparasitespeciesdonotdothis).Tu(InstituteofMateriaMedica,Acad-ThecyclebeginswhenaPlasmodium-car-Thisstageofbl
4、oodstreaminfectioncanemyofTraditionalChineseMedicineandryingfemaleanophelinemosquitofeedslastformonthsifnottreated.DuringthisChinaAcademyofChineseMedicalSci-onhumanblood.Sporozoitesinjectedstage,someparasitesleavetheasexualrep-ences)(Figure1),manyofthose249mil-intotheskinmig
5、rateviathebloodstreamlicationphaseanddifferentiateintomalelionothersmaynothavesurvived.Thisistotheliver,wheretheyinfecthepatocytes.andfemalegametocytes.OtheranophelinethestoryofhowTuledateamthattrans-Over5–16days,eachparasitegrowsmosquitoesingestingabloodmealfromformedananci
6、entChinesemethodofanddividesintothousandsofmerozo-aninfectedhumanthenmateandgenerateusingtheherbqinghaointoartemisinin,iteformsthatthenexitfromindividualthousandsofoffspringsporozoiteformsthemostpowerfulantimalarialmedicinehepatocytesintotheblood,wheretheythattraveltothemosq
7、uitosalivaryglands,thatcurrentlyexists.AndastheChineseinfecterythrocytes.SomeP.vivaxandwherethesporozoitesremainbeforeiniti-proverbhasit,“Hewhoplantsagarden,P.ovaleparasitescanremainlatentinatinganotherlifecycle(6).plantshappiness.”theliveruntiltheyactivateandcauseThefirstsy
8、mptomsinaninfectionusu-relapsesofmalariamonthsoryearslater.allyoccurtendays
