RXR介导的自噬通路在大鼠肺缺血_再灌注损伤中的调控作用

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1、温州医科大学硕士学位论文分类号：R363单位代码：10343学号：151006839硕士学位论文论文题目:RXR介导的自噬通路在大鼠肺缺血/再灌注损伤中的调控作用研究生姓名：项冰倩学科专业：病理学与病理生理学类型：学术型指导教师：王万铁教授王方岩博士二O一八年五月温州医科大学硕士学位论文论文题目:RXR介导的自噬通路在大鼠肺缺血/再灌注损伤中的调控作用答辩委员会主席：章卫平教授答辩委员会成员：薛战雄主任医师徐正祄教授论文答辩日期：2018年5月18日温州医科大学硕士学位论文目录（一）缩略词表缩略词表···················

2、·······················································1（二）论文中文摘要·········································································3英文摘要·········································································6前言····················································

3、····························10材料和方法·····································································12结果················································································37分析与讨论·····································································57结论···

4、·············································································63小结················································································63参考文献··········································································64（三）附录·······················

5、···························································70（四）致谢··················································································72（五）综述················································································73（六）参考文献···························

6、··············································87（七）独创性声明·······································································92温州医科大学硕士学位论文缩略词表简写英文全称中文全称I/RIschemia/reperfusion缺血/再灌注I/RIIschemia/reperfusioninjury缺血/再灌注损伤PIRIPulmonaryischemiareperfusioninjury肺缺血/再灌注损伤9-

7、cRA9-cisretinoicacid9-顺式维甲酸RXRRetinoidXReceptor维甲类X受体RAREretinoicacidresponseelements维甲酸反应元件IQAAlveolardamagequantitativeevaluationindex肺泡损伤评估指数WWetweight湿重DDryweight干重W/DWet/dryweightratio湿/干重比TLWTotallungwatercontent总肺水含量SODSuperoxideDismutase超氧化物歧化酶MDAMalondialdehyde丙

8、二醛MPOMyeloperoxidase髓过氧化物酶ROSReactiveoxygenspecies活性氧簇PMNPolymorphonuclearnutrophil成熟中性粒细胞GAPDHGlyceral