资源描述:
《A developmental view of microRNA function.pdf》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、ReviewTRENDSinBiochemicalSciencesVol.32No.4AdevelopmentalviewofmicroRNAfunctionYongZhaoandDeepakSrivastavaGladstoneInstituteofCardiovascularDisease,andDepartmentsofPediatricsandBiochemistryandBiophysics,UniversityofCalifornia,SanFrancisco,1650OwensStreet,SanFrancisco,CA94158,USAMicroRNA
2、s(miRNAs)aregenomicallyencodedsmallfromanother.Analysisoftheheterochronicpathwaythennon-codingRNAsthatregulateflowofgeneticinfor-ledtotheidentificationofthefirstmiRNAtarget,lin-14mationbycontrollingtranslationorstabilityofmRNAs.[3,4].ThediscoverythatanothermiRNA,let-7,iscon-Recentrecogniti
3、onthatmanymiRNAsareexpressedinaservedfromwormstomammals[5,8]resultedinthetissue-specificmannerduringdevelopmentoforganisms,realizationthatmiRNAsrepresentawidelyusedmech-fromwormstohumans,hasrevealedanovelmechanismanismtoregulatetransferofgeneticinformationinbywhichtheproteomeisregulatedd
4、uringthedynamicalmostallspecies.Overthepastfewyears,>400miRNAseventsofcell-lineagedecisionsandmorphogenesis.havebeenidentified,andthereareprobablymanymoreAdvancesintheunderstandingofmiRNAbiogenesis,stillundiscovered[9–14].Systematicanalysisofthetargetrecognitionandparticipationinregulato
5、rynet-spatialexpressionofmiRNAshasshownthatmanyworksdemonstratearoleformiRNAsinlineagedecisionsmiRNAsareexpressedinatissue-specificmannerofprogenitorcellsandorganogenesis.Futurediscoveries[15,16].BecauseeachmiRNAtargetsalargenumberofinthisareaarelikelytorevealdevelopmental-regulationmRNA
6、sfortranslationalinhibitionordegradation,itisanddiseasemechanismsrelatedtomiRNAs.likelythatmuchofthetranscriptomeisregulatedbymiRNAs.GiventhelikelyroleofmiRNAsin‘fine-tuning’Introductionproteindosage,theymightrepresentanefficientsystemInmetazoans,earlyembryonicpatterningandorganbywhichace
7、llcanrapidlycontrolthreshold-dependentmorphogenesisinvolvecoordinateddifferentiation,migra-cellularevents.tion,proliferationandprogrammedcelldeath.Thesecom-Adoptionofcelllineagesduringembryonicdevelopmentplexcellularanddevelopmentalprocessesdependonandsubsequentmorphogeneticeve