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1、CANCERIMMUNOTHERAPYThispageintentionallyleftblankCANCERIMMUNOTHERAPY:IMMUNESUPPRESSIONANDTUMORGROWTHEditedbyGeorgeC.PrendergastTheLankenauInstituteforMedicalResearchLankenauCancerCenterWynnewood,PAElizabethM.JaffeeTheSidneyKimmelComprehensiveCancerCenteratJohnsHopkinsMedicalI
2、nstituteBunting-BlausteinCancerResearchBuildingBaltimore,MDAMSTERDAMBOSTONHEIDELBERGLONDONNEWYORKOXFORDPARISSANDIEGOSANFRANCISCOSINGAPORESYDNEYTOKYOAcademicPressisanimprintofElsevierAcademicPressisanimprintofElsevier30CorporateDrive,Suite400,Burlington,MA01803,USA525BStreet,S
3、uite1900,SanDiego,California92101-4495,USA84TheobaldsRoad,LondonWC1X8RR,UKThisbookisprintedonacid-freepaper.Copyright©2007,ElsevierInc.Allrightsreserved.CoverImagecredit:PhotoofatumorcellbeingrecognizedbyanTimmunecell.CourtesyofMarcRubin,CenterforBiologicImaging,UniversityofP
4、ittsburghNopartofthispublicationmaybereproducedortransmittedinanyformorbyanymeans,electronicormechanical,includingphotocopy,recording,oranyinformationstorageandretrievalsystem,withoutpermissioninwritingfromthepublisher.PermissionsmaybesoughtdirectlyfromElseviersScience&Techno
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6、ongressCataloging-in-PublicationDataApplicationsubmitted.BritishLibraryCataloguing-in-PublicationDataAcataloguerecordforthisbookisavailablefromtheBritishLibrary.ISBN:978-0-12-372551-6ForinformationonallAcademicPresspublicationsvisitourWebsiteatwww.books.elsevier.comPrintedint
7、heUnitedStatesofAmerica07080910987654321Workingtogethertogrowlibrariesindevelopingcountrieswww.elsevier.com
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9、www.sabre.orgContentsContributorsxiPARTI:PRINCIPLESOFCANCERIMMUNOBIOLOGY1.Introduction3GeorgeC.PrendergastandElizabethM.JaffeeI.Overview3II.HistoricalBa
10、ckground3III.LookingAhead:MarryingChemotherapyandImmunotherapy5IV.Pa
