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1、ReviewForreprintorders,pleasecontactreprints@future-science.comMagneticironoxidenanoparticlesforbiomedicalapplicationsDuetotheirhighmagnetization,superparamagneticironoxidenanoparticlesinduceanimportantdecreaseinthetransverserelaxationofwaterprotonsandare,therefore,veryefficientnegativeMRIcontra
2、stagents.Theknowledgeandcontrolofthechemicalandphysicalcharacteristicsofnanoparticlesareofgreatimportance.Thechoiceofthesynthesismethod(microemulsions,sol-gelsynthesis,laserpyrolysis,sonochemicalsynthesisorcoprecipitation)determinesthemagneticnanoparticle’ssizeandshape,aswellasitssizedistributio
3、nandsurfacechemistry.Nanoparticlescanbeusedfornumerousin vivoapplications,suchasMRIcontrastenhancementandhyperthermiadrugdelivery.Newdevelopmentsfocusontargetingthroughmolecularimagingandcelltracking.Superparamagneticironoxidenanoparticlesinalkalinemedium[6].Thesecondtechnique,SophieLaurent,arew
4、idelyusedforbiotechnologyandmedi-introducedbySugimotoandMatijevic[7],Jean-LucBridot,calapplications,includingcontrastagentsforimpliestheoxidationofanaqueousferroussaltLuceVanderElst&RobertNMuller†MRI,cellrecognitionandseparationanddrugsolutionbyionnitrates,allowingtheformationof†Authorforcorresp
5、ondencedelivery[1,2].Basedontheironoxideparticles’ironoxidenanoparticleswithadiameterbetweensurfaceandtheirsize,whichinfluencethebio-30–100nm.However,mostofthepublicationsDepartmentofGeneral,distribution,someclinicalapplicationshavebeenrefertothesynthesisintroducedbyMassart[8].OrganicandBiomedic
6、aldeveloped:detectionoflivertumors,metastaticThisprocessallowsareproducibleformationofChemistry,NMRandMolecularlymphnodes,inflammatoryanddegenerativedis-sphericalparticlesingreatquantityanddoesnotImagingLaboratory,Universityeases.TheyarealsosuitableforfunctionalMRIrequireexpensivematerial.Themet
7、hodofsyn-ofMons,B-7000Mons,BelgiumtodisplaydysfunctionalprocessesonthebasisofthesisisrathersimpleandisbasedonanalkalineTel.:+3265373520cellularandmolecularmechanisms[3].coprecipitationofferrousandferricsaltprecur-Fax:+326537
