衡水市大气污染物与儿童呼吸道感染疾病的相关性分析

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1、授予单位代码10089学号或申请号13220HebeiMedicalUniversity硕士学位论文在职科学学位衡水市大气污染物与儿童呼吸道感染疾病的相关性分析学位申请人：刘娜导师：曾瑞红教授专业：免疫学二级学院：河北医科大学基础医学院起止日期：2013年12月-2015年3月2015年03月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组〉的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第一署名

2、为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名：糾佛导师签章)wpk二级学院领导盖章：Is•職年月日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章:曰目录中文摘要······························································

3、···············1英文摘要·············································································3研究论文衡水市大气污染物与儿童呼吸道感染疾病的相关性分析前言·············································································6材料与方法·································································

4、···7结果·············································································14附图·············································································17附表·············································································18讨论···························

5、··················································21结论·············································································22参考文献·······································································23综述肿瘤坏死因子-α的研究进展············································25致谢···

6、················································································32个人简历·············································································33中 文 摘 要衡水市大气污染物与儿童呼吸道感染疾病的相关性分析摘要目的：近几年，随着急剧的工业化和城市化发展，我国大部分地区出现雾霾天气，尤以中东部地区为重。主要原因是大气气溶胶的排放显著增加，其中就包括PM2.5。雾霾天

7、气频发已经严重威胁到人们的身体健康，特别是对于儿童健康的影响更加严重，儿童呼吸道特殊的解剖特点以及免疫系统发育不成熟，使得儿童更容易患呼吸系统疾病。呼吸道合胞病毒（respiratorysyncytialvirus，RSV）是引起婴幼儿呼吸道感染的主要病原之一，婴幼儿感染呼吸道合胞病毒后临床表现轻重不一，可表现为毛细支气管炎、肺炎，严重时可导致患儿死亡。RSV感染的发病机制尚未完全阐明。有研究发现，病毒感染机体后，天然免疫应答被启动，引发炎性细胞因子表达，如肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）等，在免疫保护和免疫病理中均

8、发挥重要作用。本实验分析了衡水市大气污染物与儿童呼吸道感染疾病的相关性，并考察了衡水市婴幼儿呼吸道合胞病毒的感染情况及IL-1β、TNF