Cancer epigenomics DNA methylomes and histone modification maps.pdf

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1、生生物物秀秀--专专心心做做生生物物www.bbioo.com生物秀论坛—学术交流、资源共享与互助社区http://bbs.bbioo.com生物部落—生物医药人网络家园http://Home.bbioo.com生物百科—生命科学第一百科http://Baike.bbioo.com生物秀知道—生命科学问题解决之道！http://Ask.bbioo.com易生物-领先的生物医药商务平台www.ebioe.comREVIEWSCancerepigenomics:DNAmethylomesandhistone-modificationmapsManelEs

2、tellerAbstract

3、Analteredpatternofepigeneticmodificationsiscentraltomanycommonhumandiseases,includingcancer.ManystudieshaveexploredthemosaicpatternsofDNAmethylationandhistonemodificationincancercellsonagene-by-genebasis;amongtheirresultshasbeentheseminalfindingoftranscriptionals

4、ilencingoftumour-suppressorgenesbyCpG-island-promoterhypermethylation.However,recenttechnologicaladvancesarenowallowingcancerepigeneticstobestudiedgenome-wide—anapproachthathasalreadybeguntoprovidebothbiologicalinsightandnewavenuesfortranslationalresearch.Itistimeto‘upgrade’can

5、cerepigeneticsresearchandputtogetheranambitiousplantotacklethemanyunansweredquestionsinthisfieldusingepigenomicsapproaches.EndoparasiticsequencesTheepigeneticlandscapeofcancercellsisprofoundlypatternsincancercells,andtheprognostic,diagnosticandRepeatedsequences,mostdistorted.Hu

6、mantumoursundergoamassiveoveralltherapeuticimpactofepigenomicprofiling.IconcludeofwhicharederivedfromlossofDNAmethylation,butalsoacquirespecificpat-bydiscussingthefutureofcancerepigenomicsinthetransposableelements.Theseternsofhypermethylationatcertainpromoters1–4.Inlightoflarge

7、-scale,coordinatedeffortstocataloguesequencesarepropagatedaddition,theseDNA-methylationchangesarelinkedthehumanepigenome.byinsertingnewcopiesofthemselvesintorandomsiteswiththepresenceofanaberrantpatternofhistoneinthegenome.modification5–9.Small-scalestudiesofepigeneticmarksEpig

8、eneticmarksinnormalandcancercellshaveprovidedimportantinsightsintocancerbiology;www.bbioo.comDNAmethylationandhistonemodificationshaveforexample,thehypermethylationoftumour-suppressorcrucialrolesinthecontrolofgeneactivityandnucleargenes,whichisassociatedwiththeirtranscriptional

9、architecture.Themostwidelystudiedepigeneticmodi-silenc