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1、MechanobiologyofCell‐CellandCell‐MatrixInteractionsA.WagonerJohnsonlBrendanA.C.HarleyEditorsMechanobiologyofCell‐CellandCell‐MatrixInteractionsEditorsA.WagonerJohnsonBrendanA.C.HarleyDepartmentofMechanical&IndustrialDepartmentofChemical&BiomolecularEngineeringEngi
2、neeringUniversityofIllinois,Urbana‐ChampaignUniversityofIllinois,Urbana-Champaign1206W.GreenSt.600S.MathewsAve.Urbana,Illinois61801Urbana,Illinois61801USAUSAajwj@illinois.edubharley@illinois.eduISBN978-1-4419-8082-3e-ISBN978-1-4419-8083-0DOI10.1007/978-1-4419-8083
3、-0SpringerNewYorkDordrechtHeidelbergLondonLibraryofCongressControlNumber:2011921261#SpringerScienceþBusinessMedia,LLC2011Allrightsreserved.Thisworkmaynotbetranslatedorcopiedinwholeorinpartwithoutthewrittenpermissionofthepublisher(SpringerScience+BusinessMedia,LLC,
4、233SpringStreet,NewYork,NY10013,USA),exceptforbriefexcerptsinconnectionwithreviewsorscholarlyanalysis.Useinconnectionwithanyformofinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodologynowknownorhereafterdevelopedisf
5、orbidden.Theuseinthispublicationoftradenames,trademarks,servicemarks,andsimilarterms,eveniftheyarenotidentifiedassuch,isnottobetakenasanexpressionofopinionastowhetherornottheyaresubjecttoproprietaryrights.Printedonacid-freepaperSpringerispartofSpringerScience+Busin
6、essMedia(www.springer.com)PrefaceCellbehaviorismodulatedbyacomplex,spatio-temporallyintegratedsetofbiophysicalmechanismsinfluencedbythebiochemistryofextracellularandintra-cellularsignaling,butalsobythepropertiesofthesurroundingextracellularenvironment.Acellassimila
7、tesmultiplecuesfromitsmicroenvironment,includingsignalsboundtotheextracellularmatrixandneighboringcells,mechanicalstimuli,andsolublesignalsfrombothadjacentanddistantcells.Thecellthenrespondstothesesignalsviamultiplepathways,eachinvolvingmultiplecascadesofinternalm
8、olecularinteractions.Whilemuchasbeenlearnedoverthepastdecaderegardingthemechanobiologyofhowcellsinteractwiththeirsurroundingenvironmentincasesofphysiolo
