不同浓度17β-雌二醇对il-1β诱导的大鼠纤维环细胞凋亡的影响

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1、授予单位代码10089学号或申请号20122239对妗6钭大交HebeiMedicalUniversity硕士学位论文科学学位不同浓度17p-雌二醇对凋亡的—响IL-lp诱导的大鼠纤维环细胞研究生：王海莹导师：丁文元教授专业：外科学二级学院：第二医院2015年3月河：！匕医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名为单

2、位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。，：：研究生签名：在对1导师签章二级学院领等舍亨：•>^、夕：、:‘、錄•/^ur二年漆月i日/河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：晃汝元导师签章：年孓月>曰目录中文摘要······························

3、···············································1英文摘要·············································································3英文缩写·············································································6研究论文不同浓度17β-雌二醇对IL-1β诱导的大鼠纤维环细胞凋亡的影响前言···············

4、······························································6材料与方法····································································7结果·············································································12附图·············································

5、································14附表·············································································16讨论·············································································17结论···································································

6、··········20参考文献·······································································21综述炎症因子在椎间盘退变中作用的研究进展··························27致谢···················································································42个人简历·····································

7、········································43中文摘要不同浓度17β-雌二醇对IL-1β诱导的大鼠纤维环细胞凋亡的影响摘要目的:椎间盘退行性病变是指随着年龄的增长，椎间盘各组织发生的老化退变。是导致许多脊柱退行性疾病的前提和基础，如椎管狭窄、椎间盘突出、脊柱不稳等。虽然目前导致椎间盘退变的确切机制还不清楚，但大多数学者认为椎间盘的退变是多因素共同作用的结果。椎间盘细胞数量的减少以及细胞外基质成分的改变是椎间盘退变的病理生理基础，而髓核及纤维环细胞的凋亡是椎间盘细胞减少的主要原因。研究发现

8、退变的椎间盘组织能够产生大量的炎症因子，其中IL-1β是一种能导致炎症反应及细胞凋亡的多效性细胞因子，在椎间盘细胞凋亡中起重要作用。临床观察发现绝经后妇女与同年龄男性相比，椎间盘退行性疾病的发病率较高，提示雌激素与椎间盘退变有关。近年来，研究发现雌激素有抗软骨细胞及胰腺β细胞凋亡的作用，雌