参芎葡萄糖注射液联合辛伐他汀防治兔颈动脉球囊损伤术后内膜增生的实验研究

《参芎葡萄糖注射液联合辛伐他汀防治兔颈动脉球囊损伤术后内膜增生的实验研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予年.位代码10089_学号或申请号13936HebeiMedicalUniversity士学位论文在职科学学位参芎葡萄糖注射液联合辛伐他汀防治兔颈动脉球囊损伤术后内膜增生的实验研究学位申请人：王雅男导师：信栓力教授专业：内科学二级学院：邯郸市第一医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相

2、关的论文,第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则,承担相应法律责任。研究生签名:茗导师签章：二级学院领导盖章：io'I年[月M日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名：唤导师签章：>【jT年S目录中文摘要···························

3、···················································1英文摘要··············································································3英文缩写··············································································6研究论文参芎葡萄糖注射液联合辛伐他汀防治兔颈动脉球囊损伤术后内膜增生的实

4、验研究前言··············································································8材料与方法····································································10结果·············································································14附图············

5、·································································16附表·············································································18讨论·············································································20结论·······················

6、······················································23参考文献·······································································23综述动脉粥样硬化形成机制及干预治疗研究进展·······················28致谢·········································································

7、··········40个人简历·············································································41中文摘要参芎葡萄糖注射液联合辛伐他汀防治兔颈动脉球囊损伤术后内膜增生的实验研究摘要目的：1探讨对高脂喂养的兔，施以参芎葡萄糖注射液、辛伐他汀干预后的血脂、血糖及血清TXB2、P-selectin水平的变化。2探讨参芎葡萄糖注射液联合辛伐他汀对防止高脂血症的兔颈总动脉球囊损伤后内膜增生的作用。方法：40只健康的2.5-

8、3.0kg新西兰兔（雄性），随机分为5组，每组8只：1对照（C）组，给予高脂饲料120~150g/d喂养10周；2球囊损伤（H）组，给予高脂饲料120~150g/d喂养10周；3辛伐他汀（S）组，给予高脂饲料120~150g/d喂养10周，同时给予辛伐他汀2.2mg/(kg.d)配制于饲料内口服；4参芎葡萄糖（SX）组，给予高脂饲料120~150g/d喂养10周，同时给予参芎葡萄糖注射液腹腔注射5ml/（kg.d）；5参芎葡萄糖+辛伐他汀（