《adjunctivearipiprazoleinthetreatmentofrisperidone-inducedhyperprolactinemiaarandomized,double-blind,placebo-control

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1、Psychoneuroendocrinology(2015)58,130—140Availableonlineatwww.sciencedirect.comScienceDirectjournalhomepage:www.elsevier.com/locate/psyneuenAdjunctivearipiprazoleinthetreatmentofrisperidone-inducedhyperprolactinemia:Arandomized,double-blind,placebo-contr

2、olled,dose—responsestudyJing-Xua,1b,1aaChen,Yun-AiSu,Qing-TaoBian,Li-HeWei,Zhangaac,Yan-HongRong-ZhenLiu,ChristophCorrell,JairdaaC.Soares,Fu-DeYang,Shao-LiWang,Zhanga,d,∗Xiang-YangaBeijingHui-Long-GuanHospital,PekingUniversity,Beijing100096,ChinabPeking

3、UniversitySixthHospital/InstituteofMentalHealth,KeyLaboratoryofMentalHealth,MinistryofHealth,PekingUniversity,Beijing,ChinacTheZuckerHillsideHospital,PsychiatryResearch,NorthShore-LongIslandJewishHealthSystem,GlenOaks,NY,USAdDepartmentofPsychiatryandBeh

4、avioralSciences,HarrisCountyPsychiatricCenter,TheUniversityofTexasHealthScienceCenteratHouston,Houston,TX,USAReceived14January2015;receivedinrevisedform27March2015;accepted16April2015KEYWORDSSummaryHyperprolactinemiaisanunwantedadverseeffectassociatedwi

5、thseveralantipsy-chotics.Risperidone;Theadditionofpartialdopaminereceptoragonistaripiprazolemayattenuateantipsychotic-inducedAripiprazole;hyperprolactinemiaeffectively.However,theidealdosingregimenforthisProlactin;purposeisunknown.Weaimedtoevaluatethedo

6、seeffectsofadjunctivetreatmentwitharipiprazoleHyperprolactinemia;onprolactinlevelsandhyperprolactinemiainschizophreniapatients.Stablesub-jects18—45Intervention;yearsoldwithschizophreniaandhyperprolactinemia(i.e.,>24ng/mlforfemalesand>20ng/mlPlaceboforma

7、les)wererandomlyassignedtoreceive8weeksofplacebo(n=30)orcontrolledoraltrial;aripiprazole5mg/day(n=30),10mg/day(n=29),or20mg/day(n=30)addedontofixeddoserisperidonetreatment.DoseSerumprolactinlevelsweremeasuredatbaselineandafter2,4effectand8weeks;clinicals

8、ymptomsandsideeffectswereassessedatbaselineandweek8using∗Correspondingauthorat:HarrisCountyPsychiatricCenter,2800SouthMacGregorWay,Houston,TX77021,USA.Tel.:+17137416047;fax:+17134862552.E-mailaddress:xiang.y.zhang@uth.tmc.edu(X.-