可溶性补体受体2在干燥综合征患者血清中的变化及意义

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1、ImmunologyStudies免疫学研究,2014,2,17-22PublishedOnlineMay2014inHans.http://www.hanspub.org/journal/ishttp://dx.doi.org/10.12677/is.2014.22004ChangesandSignificanceofSerumSolubleComplementReceptor2inPatientswithPrimarySjogren’sSyndromeNingningLi1,YongliZhang1*,XiaofeiWang2,YunhuaHou1

2、,XiaoyangYing1,ChenchenWang1,TingZhang1,YingLiu1,FangWang31AffiliatedZhongshanHospitalofDalianUniversity,Dalian2ShengJingHospitalofChinaMedicalUniversity,Shenyang3TheCentralHospitalofLiaoyang,Liaoyang*Email:ning12161121@163.com,Zhangyongli8822@126.comthththReceived:Apr.9,2014;re

3、vised:May10,2014;accepted:May15,2014Copyright©2014byauthorsandHansPublishersInc.ThisworkislicensedundertheCreativeCommonsAttributionInternationalLicense(CCBY).http://creativecommons.org/licenses/by/4.0/AbstractAim:Changesandsignificanceofserumsolublecomplementreceptor2(sCR2)inpa

4、tientswithprimarySjogren’ssyndrome(pSS)arediscussed.Methods:ELISAwasdevelopedforthedeter-minationofserasCR2concentrationinseraof20pSSpatientsand20healthyvolunteers.Statis-ticalanalysiswasperformedbyusingSPSSsoftware.Results:ThelevelofserumsCR2inpatientswithpSSwassignificantlylow

5、erthanthatinhealthycontrol(P<0.01).Inaddition,therewasnocorrelationbetweenpatients’ageandsexinsCR2levels.ThelevelofserumsCR2intheself-anti-bodypositivegroupwaslowerthanthatinthenegativecontrolgroup,andtherewassignificantstatisticalsignificance(P<0.05).Inaddition,thelevelofserums

6、CR2inpSSpatientsshowednega-tivecorrelationwithimmunoglobulinIgGandESRlevel.Conclusions:Theevidentdecreaseofse-rumsCR2levelinpSSpatientshasnegativecorrelationwiththelevelsofimmunoglobulinIgGandESR,whichsuggeststhatsCR2mayplayacriticalroleinthepathogenesisofpSS.KeywordsPrimarySjog

7、ren’sSyndrome,SolubleComplementReceptor2*通讯作者。17可溶性补体受体2在干燥综合征患者血清中的变化及意义可溶性补体受体2在干燥综合征患者血清中的变化及意义11*2111113李宁宁，张永利，王晓非，侯云华，应晓杨，王晨辰，张婷，刘影，王芳1大连大学附属中山医院，大连2中国医科大学附属盛京医院，沈阳3辽阳市中心医院，辽阳*Email:ning12161121@163.com,Zhangyongli8822@126.com收稿日期：2014年4月9日；修回日期：2014年5月10日；录用日期：2014年5月15日摘

8、要目的：探讨原发性干燥综合征(pSS)患者血清中可溶性补体受体2(sCR2)的变化及意义。方法