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时间:2019-05-15
《托吡酯单一治疗抽动秽语综合征的远期疗效》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、浙江大学硕士学位论文托吡酯单一治疗抽动秽语综合征的远期疗效姓名:刘健申请学位级别:硕士专业:神经病学指导教师:潘以正2003.4.1浙江大学硕士学位论文托吡酯单一治疗抽动秽语综合征的远期疗效浙江大学医学院神经内科学2000级硕士研究生(专业学位)刘健导师潘以正【摘要】目的探讨托吡酯治疗Tourette综合征(TS)的疗效和安全性。方法将53例TS忠儿按病例编号分为试验组(35例)和对照组(18例)。试验组予托吡酯治疗,滴定法加量,每周增加25mg,最大剂量不超过150mg;对照组使用氟哌啶醇(1.5-6rag/d),共治疗24周。试验组3
2、例脱落,对照组2例脱落。采用美国耶鲁YGTSS综合量表、副反应量表(TESs),于治疗前、治疗8周末、24周末对两组进行评估。结果治疗8周末时治疗组有效率为72、O%,高于对照组37.5%(P=0.001)。试验组YGTSS总分[(28,06士14.45)分]低于对照组[(40.00-a:20.90),P<0.05]:减分率【(48.10士22.80)%】高于[(33.1)士31.90)%,P>0.05]。24周末时有效率为81.2%,高于对照组56.2%(P3、(36.50-a:21.08);P<0.05】;减分率【(52.90-3:24.49)%】高于对照组[(34.63士32.58)%:P<0.05]。试验组的副发应评分8周末[(4.88士3.67)分】低于对照组[(6.25士4.06)分:P<0.05】,24周末【(2.81士2.66)分】低于对照组【(3.58士3.90)分;P<0.05]。结论托毗酯能有效改善TS的运动、发声抽动和综合损伤效应,副作用相对较轻。【关键词】抽动秽语≥景备征:托吡酯;治疗、/、l/鼻塑、江奎堂堡主堂垡堕茎一——Lateresultoftopiramateas4、singletreatmentinTourettesyndromeCollegeofMedicalSciences,ZhejiangUniversityNeurology2000gradepostgraduateLiujianSupervisorPanYizheng[Abstract]0bjectiveTheaimofthisNudywastodeterminetheefficacyandsafetyoftreatingTourette’ssyndromewithtopiramate.MethodsAopen—controlledstud5、ywascarriedout.Fifty-threepatientswhomettheDSV⋯IVRcriteriaforTSwasinvolvedinthestudy.Subjectsreceived24一weekmedicationcyclesoftopiramate(50~150mg/d)andcontrol、^rimhaloperidol(1.5-6mg/d).TheefficacywasassessedbytheYaleGlobalTicSeverityScale(YGTSS)andthesafetyassessedwithth6、eTreatmentEmergentSymptomScale.Measureswereassessedatbaselineandonweeks8.24ofthestudy.ResultsForty—eightsubjectscompletedtheprotoc01.Thirty。twosubjectstreatedwithtopiramateandsixteenoneswithhaloperid01.Threedropped、Ⅳitlltoperamate.twodroppedforsevereextrapyramidaladverser7、eactionwithhaloperid01.Theefficacyoftheresearchgroupwassignificantlybetterthanthecontrolgroup.8weekslateLtheeffectiveratewas72.0%intheresearchgroupas37.5%inthecontr01.ThetotalYGTSSscoreshowedsignificance(P<0.05)thou曲nodifferenceinthedecreaserate.24weekslater,theeffectiver8、atewas81.2%intheresearchgroupas56.2%inthecontr01.boththetotalYGTSSscoreanddecreaserateshowedsign
3、(36.50-a:21.08);P<0.05】;减分率【(52.90-3:24.49)%】高于对照组[(34.63士32.58)%:P<0.05]。试验组的副发应评分8周末[(4.88士3.67)分】低于对照组[(6.25士4.06)分:P<0.05】,24周末【(2.81士2.66)分】低于对照组【(3.58士3.90)分;P<0.05]。结论托毗酯能有效改善TS的运动、发声抽动和综合损伤效应,副作用相对较轻。【关键词】抽动秽语≥景备征:托吡酯;治疗、/、l/鼻塑、江奎堂堡主堂垡堕茎一——Lateresultoftopiramateas
4、singletreatmentinTourettesyndromeCollegeofMedicalSciences,ZhejiangUniversityNeurology2000gradepostgraduateLiujianSupervisorPanYizheng[Abstract]0bjectiveTheaimofthisNudywastodeterminetheefficacyandsafetyoftreatingTourette’ssyndromewithtopiramate.MethodsAopen—controlledstud
5、ywascarriedout.Fifty-threepatientswhomettheDSV⋯IVRcriteriaforTSwasinvolvedinthestudy.Subjectsreceived24一weekmedicationcyclesoftopiramate(50~150mg/d)andcontrol、^rimhaloperidol(1.5-6mg/d).TheefficacywasassessedbytheYaleGlobalTicSeverityScale(YGTSS)andthesafetyassessedwithth
6、eTreatmentEmergentSymptomScale.Measureswereassessedatbaselineandonweeks8.24ofthestudy.ResultsForty—eightsubjectscompletedtheprotoc01.Thirty。twosubjectstreatedwithtopiramateandsixteenoneswithhaloperid01.Threedropped、Ⅳitlltoperamate.twodroppedforsevereextrapyramidaladverser
7、eactionwithhaloperid01.Theefficacyoftheresearchgroupwassignificantlybetterthanthecontrolgroup.8weekslateLtheeffectiveratewas72.0%intheresearchgroupas37.5%inthecontr01.ThetotalYGTSSscoreshowedsignificance(P<0.05)thou曲nodifferenceinthedecreaserate.24weekslater,theeffectiver
8、atewas81.2%intheresearchgroupas56.2%inthecontr01.boththetotalYGTSSscoreanddecreaserateshowedsign
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