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时间:2019-05-16
《不同剂量阿托伐他汀治疗心肌梗死合并心衰患者的效果对比》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中国心血管病研究2012年3月第10卷第3期ChineseJournalofCardiovascularResearch,March2012,Vol·10,No.3.203.不同剂量阿托伐他汀治疗心肌梗死合并心衰患者的效果对比Theefectscomparativeanalysisofdiferentdosesofatorvastatininpatientswithmyocardialinfarctioncomplicatedbyheartfailure梁棕梁转合作者单位:529100广东省,江门市新会区人民医院急救中心(梁棕),心血管内科(梁转合)【摘要】目的观察对比
2、不同剂量阿托伐他汀治疗心肌梗死合并心衰患者的临床效果。方法选取我院2009年5月至2011年5月42例心肌梗死合并心衰的患者,均行经皮冠状动脉介入术(PCI),随机分为观察组和对照组,各2l例。观察组患者术前El服40mg/d阿托伐他汀;对照组患者术前口服20mg/d阿托伐他汀,观察比较两组患者入院前24h、术前1d、术后1d、术后3d、术后4周血清高敏C一反应蛋白(hs—CRP)的变化。结果两组术后3d血清hs—CRP与入院前24h、术前1d相比差异有统计学意义(P3、CI术前给予口服40mg/d阿托伐他汀治疗,能有效降低血清中的炎症因子,增高血清中的炎症保护因子,从而保护心功能。【关键词】阿托伐他汀;心肌梗死;心力衰竭;经皮冠状动脉介入术doi:10.3969/j.issn.1672-5301.2012.03.012中图分类号R542.242文献标识码A文章编号1672—5301(2012)03—0203—03Theefectscomparativeanalysisofdiferentdosesofatorvastatininpatientswithmyocardialinfarctioncomplicatedbyheartfail4、ureLIANGZong,LIANGZhuan—he.EmergencyCenterofJiangmenCityXinhuiDistrictPeople’SHospital,Jiang—men5291O0,China[Abstract]ObjectiveToobservetheefleetsofdiferentdosesofatorvastatininthetreatmentofmvocar—dialinfarctioncomplicatedwithheartfailure.MethodsFromMay2009toMay2011,42casesofpatientswit5、hmyocardialinfarctioncomplicatedbyheartfailureunderwentpercutaneouscoronaryintervention(PCI)inourhospi-talwereenrolled.Thepatientswererandomlydividedintoobservationgroup(n=21)andthecontrolgroup(n=21).Theobservationgrouptook40mg/dofatorvastatinpreoperation,andthecontrolgrouptook20mg/dofat6、orvas—tatinpreoperation.Serumlevelsofhigh-sensitivityC—reactiveprotein(hs-CRP)intwogroupsweremeasuredafteradmission24h,preoperative1d,3dand4weekspostoperation.ResultsTheserumlevelofhs-CRPin3dpostoperativewassignificantlyhigherthanadmissionand1dpreoperation(P<0.05)intWOgroups.Thelevelofhs7、—CRPpostoperative3dwassignificantlydiferentbetweentwogroups(P
3、CI术前给予口服40mg/d阿托伐他汀治疗,能有效降低血清中的炎症因子,增高血清中的炎症保护因子,从而保护心功能。【关键词】阿托伐他汀;心肌梗死;心力衰竭;经皮冠状动脉介入术doi:10.3969/j.issn.1672-5301.2012.03.012中图分类号R542.242文献标识码A文章编号1672—5301(2012)03—0203—03Theefectscomparativeanalysisofdiferentdosesofatorvastatininpatientswithmyocardialinfarctioncomplicatedbyheartfail
4、ureLIANGZong,LIANGZhuan—he.EmergencyCenterofJiangmenCityXinhuiDistrictPeople’SHospital,Jiang—men5291O0,China[Abstract]ObjectiveToobservetheefleetsofdiferentdosesofatorvastatininthetreatmentofmvocar—dialinfarctioncomplicatedwithheartfailure.MethodsFromMay2009toMay2011,42casesofpatientswit
5、hmyocardialinfarctioncomplicatedbyheartfailureunderwentpercutaneouscoronaryintervention(PCI)inourhospi-talwereenrolled.Thepatientswererandomlydividedintoobservationgroup(n=21)andthecontrolgroup(n=21).Theobservationgrouptook40mg/dofatorvastatinpreoperation,andthecontrolgrouptook20mg/dofat
6、orvas—tatinpreoperation.Serumlevelsofhigh-sensitivityC—reactiveprotein(hs-CRP)intwogroupsweremeasuredafteradmission24h,preoperative1d,3dand4weekspostoperation.ResultsTheserumlevelofhs-CRPin3dpostoperativewassignificantlyhigherthanadmissionand1dpreoperation(P<0.05)intWOgroups.Thelevelofhs
7、—CRPpostoperative3dwassignificantlydiferentbetweentwogroups(P
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