萘酰亚胺和罗丹明类新功能性荧光染料的研究

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1、大连理工大学博士学位论文萘酰亚胺和罗丹明类新功能性荧光染料的研究姓名：付梅艳申请学位级别：博士专业：精细化工指导教师：肖义20090601萘酰亚胺和罗丹明类新功能性荧光染料的研究其HOMO能级，特殊的6枣-兀掌共轭作用降低了其LUMO能级，二者的协同作用大大减小了能隙能量，使吸收和荧光光谱明显红移。关键词：萘酰亚胺；探针；硅杂罗丹明；长波长荧光染料；大连理工大学博士学位论文TheResearchonNewFunctionalFluorescentDyesBasedonNaphthalimdesandRhodami

2、nesAbstractThenaphthalimidesandrhodamineshavehadgreatattentionbecauseoftheirgoodphotochemicalandphotophysicalproperties．Naphthalimideshadlargepotentialapplicationmarketinvariousfields，80itwasachanceandachallengeforUStodevelopmorefunctionalderivativesofnaphtha

3、limidewitllbetterproperties．Sincetheextentisivelyappilicationofrhodaminesinbioliogicalenvironment，itWasnecessaryandurgenttodevelopmorekindsofsuchlongwavelengthrhodaminederivativestomeettheincreasingdemands．Inthiswork,threekindsoffluorescentsensorsbasedonnapht

4、halimdesandonekindofsilicon-substitutedrhodaminedyes、7lritlllongabsorptionandemissionwavelengthhadbeensynthsized．1．ThenewPETfluorescentprotonsponges．A1．A2andA3hadsynthesizedbasedonnaphthalimides．D^嗄A卜iWasprovedagoodprotonreceptorunittodevelopsensitivefluoresc

5、entswitchestriggeredbylower-concentrationproton．A3exhibitedsignificantfluorescenceenhancementuponprotonationinhighpH(pH=12．9)aqueoussolutions，thepKaofwhichwas11．ThelowestdetectionconcentritionWas1．25xl0以’mol／L．2．Basedontheapproachofswitchingo行FRETbywreckingth

6、eacceptorpart,cassette-typesensors(SN-1，SN一2andSN-3)forfluorideanioncontainingnaphthalimideandsquaraineunitshasbeendeveloped．Thesesensorsshowsensitiveresponsetofluorideanionthroughbothnaked·eyedetectablecolourchangesandratiometricfluorescencechanges．，nledetec

7、tionprocesswasrealizedbythecombinationofthereactiverecognitionandFRETmechanism．SN-2andSN．3showedexcellentratiometricfluorescencechangeswhichmadethequantitivemeasurementtobeavaliable．ThedetectionlimitandequilibriumconcentrionofF。forSN一2Was2洲and1．2mMwithshortre

8、actiontime(3min)．ThedetectionlimitandequilibriumconcentrionofF‘forSN-3Was1IxMand50州谢tllthereactiontimeabout30min．3．TwochiralfluorephoresNNHandNNMhadbeensynthesizedbyintroducingthechiralce