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1、Availableonlineatwww.sciencedirect.comAvailableonlineatwww.sciencedirect.comProcediainVaccinology5(2011)84–105ProcediainVaccinology5(2011)84–105#NICEATM-ICCVAMInternationalWorkshoponAlternativeMethodstoReduce,Refine,andReplacetheUseofAnimalsinVaccinePotencyandSafetyTesting:StateoftheScie
2、nceandFutureDirectionsBethesda,Maryland,USA,14-16September2010Improvinganimalwelfareandreducinganimaluseforveterinaryvaccinepotencytesting:stateofthescienceandfuturedirectionsabcdWilliamSStokes*,KarenBrown,JodieKulpa-Eddy,GeethaSrinivas,MarlieseffghiHalder,HansDraayer,JeffreyGalvin,IvoCl
3、aassen,GlenGifford,RalphWoodland,jjVivianDoelling,andBrettJonesaNationalToxicologyProgramInteragencyCenterfortheEvaluationofAlternativeToxicologicalMethods,DivisionoftheNationalToxicologybProgram,NationalInstituteofEnvironmentalHealthSciences,ResearchTrianglePark,NorthCarolina,USA,PairO'
4、DocsEnterprises,cParkville,Missouri,USA,UnitedSatesDepartmentofAgriculture-AnimalandPlantHealthInspectionService-VeterinaryServices,Riverdale,dMaryland,USA,UnitedStatesDepartmentofAgriculture-AnimalandPlantHealthInspectionService-CenterforVeterinaryBiologics,Ames,eIowa,USA,EuropeanCommis
5、sionJointResearchCentre,InstituteforHealthandConsumerProtection,EuropeanCentrefortheValidationoffgAlternativeMethods,Ispra,ItalyPfizerAnimalHealth,Lincoln,Nebraska,USA,CentralVeterinaryInstitute,Lelystad,TheNetherlands,hiCanadianFoodInspectionAgency–CanadianCentreforVeterinaryBiologics,O
6、ttawa,Ontario,Canada,VeterinaryMedicinesDirectorate,jSurrey,UnitedKingdom,IntegratedLaboratorySystems,Inc.,ResearchTrianglePark,NorthCarolina,USAAbstractVeterinaryvaccinescontributetoimprovedhumanandanimalhealthandwelfarebypreventingdiseasesanddeathscausedbyawiderangeofinfectiousagents.H
7、owever,testingnecessarytoensurevaccineeffectivenessandsafetycaninvolvelargenumbersofanimalsandsignificantpainanddistress.NICEATMandICCVAMconvenedaninternationalworkshoptoreviewthestateofthescienceofhumanandveterinaryvaccinepotencyandsafetytestingmethodsandtoidentifyopport