核磁共振波谱（兰州大学） Chapter 4_C13 NMR spectroscopy

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1、Chapter413CNMRSpectrometry13CI=½,NMRdetectable,butNaturalabundanceisonly1.1%thatof12CSensitivityisonly1.6%thatof1H12CI=0,NMRundetectableTheoverallsensitivityof13C/1His1/570013CNMRSpectrumwithProton-Coupling31562434561213CNMRSpectrumwithProtonsDecoupledbytheBroadbandDecoupler31562

2、434561213CNMRSpectrumwithProtonsDecoupledanda10-sDelaybetweenPulses315624463521FreeInductionDecay(TimeDomain)andFourierTransformed13CNMRSpectrum(FrequencyDomain),DecoupledCHOH3FIDCH3FT13CNMRFreeInductionDecay(TimeDomain)andFourierTransformed13CNMRSpectrum(FrequencyDomain),Decoupl

3、edCH3-CH2-OHFTCH2CH313CNMRSchematicRepresentationoftherfPulseFollowedbytheFIDandPulseDelayFIDFIDpulsepulsedelaydelayrfrf13CNMRwithProtonsDecoupledbytheBroadbandDecoupler:AnExample(CH)C-OH(CH3)333C13CNMRTMS13CNMRwithProtonsDecoupledbytheBroadbandDecoupler:AnExample124313CNMRwithPr

4、otonsDecoupledbytheBroadbandDecoupler:AnExample13CNMRChemicalShifts:InductiveEffectofSubstituentsonAlkanes13CNMRChemicalShifts:InductiveEffectofSubstituentsonAlkanesandCycloalkanes18.673.827.99.829.511.3αγγββ36.2HOHO69.5NS69.529.147.935.527.727.827.824.424.926.625.925.913CNMRChem

5、icalShifts:γGaucheInteractiononAlkanesγgaucheinteractionHYYHθCγαγβCγΔδ=CF(γ)cosθY=N,O,FstHHHHantigauche13CNMRChemicalShifts:γGaucheInteractiononCycloalkanes–3.97–6.32–8.37–4.22–17.79–6.2013CNMRChemicalShifts:γGaucheInteractiononCycloalkanesCOOHHH2025COOH13CNMRChemicalShifts:Effec

6、tsofSubstituentsonAlkenes123.213CNMRChemicalShifts:ConjugativeEffectsofSubstituentsonAlkenes123.213CNMRChemicalShifts:InductiveEffectsofSubstituentsonAlkenesandCycloalkenes122.0126.1153.2BrClOCH3115.0117.584.2128.7141.7C-OCH3O-C-CH3129.996.4OO107.1O149.7127.336.2129.322.128.9150.

7、724.526.213CNMRChemicalShifts:EffectofSubstituentsonAlkynes128.6135.4122.777.4128.9CH83.813CNMRChemicalShifts:InductiveandConjugativeEffectsofSubstituentsonAromaticCompoundsClOHOCH3NH2128.5148.6155.1147.7159.8134.9126.5128.7115.7116.1113.5129.8129.5128.5129.5130.1120.5126.5119.01

8、26.0121.4119.2OCN112.5136.1122.7137.8132