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1、AntiviralResearch92(2011)389–407ContentslistsavailableatSciVerseScienceDirectAntiviralResearchjournalhomepage:www.elsevier.com/locate/antiviralReviewÒqNanobodies:Newammunitiontobattlevirusesa,⇑aa,1b,cb,cPeterVanlandschoot,CatelijneStortelers,ElsBeirnaert,LorenaItatíIbañez,BertSchepens,ab,cErikDepl
2、a,XavierSaelensaAblynxNV,Technologiepark21,B-9052Ghent,BelgiumbDepartmentofMolecularBiomedicalResearch,VIB,Technologiepark927,B-9052Ghent,BelgiumcDepartmentofBiomedicalMolecularBiology,GhentUniversity,Technologiepark927,B-9052Ghent,BelgiumarticleinfoabstractArticlehistory:In1989,anewtypeofantibody
3、wasidentified,firstintheseraofdromedariesandlateralsoinallotherReceived8July2011speciesoftheCamelidaefamily.Theseantibodiesdonotcontainalightchainandalsolackthefirstcon-Revised30August2011stantheavydomain.Todayitisstillunclearwhattheevolutionaryadvantageofsuchheavychain-onlyAccepted6September2011anti
4、bodiescouldbe.Insharpcontrast,thebroadapplicabilityoftheisolatedvariableantigen-bindingAvailableonline10September2011domains(VHH)wasrapidlyrecognized,especiallyforthedevelopmentoftherapeuticproteins,calledÒNanobodies.HerewesummarizefirstsomeoftheuniquecharacteristicsandfeaturesofVHHs.TheseKeywords:
5、willnextbedescribedinthecontextofdifferentexperimentaltherapeuticapplicationsofNanobodiesNanobodyagainstdifferentviruses:HIV,HepatitisBvirus,influenzavirus,RespiratorySyncytialvirus,Rabiesvirus,CamelidaeHeavychain-onlyantibodyFMDV,Poliovirus,Rotavirus,andPERVs.Next,thediagnosticapplicationofVHHs(Va
6、cciniavirus,Mar-VHHburgvirusandplantTulipvirusX),aswellasanindustrialapplication(lyticlactococcal936phage)willAntiviralbedescribed.Inaddition,thedescribeddatashowthatmonovalentNanobodiescanpossessuniquechar-acteristicsnotobservedwithconventionalantibodies.Thestraightforwardformattingintobivalent,m
7、ul-tivalent,and/ormultispecificNanobodiesallowedtailoringmoleculesforpotencyandcross-reactivityagainstviraltargetswithhighsequencediversity.Ó2011PublishedbyElsevierB.V.Contents1.Introduction.......................
