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1、AttakornPalasuwanetalRESEARCHCOMMUNICATIONInhibitionofHeinzBodyInductioninaninVitroModelandTotalAntioxidantActivityofMedicinalThaiPlantsAttakornPalasuwan1,SuphanSoogarun1,TamapornLertlum1,PaweenaPradniwat1,VirojWiwanitkit2AbstractHerbshavebeenusedformedicinalpurposesforcenturiesandknownt
2、opossessantioxidantpropertiesthatmayhelptoreducetheriskofchronicdiseases,cardiovasculardisease,andcancer.Wescreenaqueousextractsfrom20medicinalplantsinThailandthatwerebelievedtopossessanti-tumoractivity,helpimmune-stimulatingpropertyandmaintainbloodstasis.Theantioxidantactivitieswereinve
3、stigatedintwobioassays.Firstly,wedemonstratedinhibitionofHeinzbodiesinductioncausedbyoxidantsunderinvitrocondition.ThepercentagesofHeinzbodyinhibitionactivityinplantextractsfromTerminaliacitrina,Cassiatimoriensis,andDerrisellipticawerethehighestfollowedbyAnamirtacocculus,andOroxylumindic
4、umrespectively.Inaddition,weinvestigatedtotalantioxidantactivityinplantextractsbyimprovedABTSradicalcationdecolorizationassay.ThetotalantioxidantactivityoftheextractfromTerminaliacitrinawasalsothehighestactivityfollowedbyFicuspubigera,Derriselliptica,Anamirtacocculus,Caesalpiniasappan,an
5、dOroxylumindicumrespectively.OurresultssuggestmedicinalThaiplantsasvaluablesourcesofantioxidants,whichmayhaveapotentialanti-carcinogenicactivity.KeyWords:Antioxidantactivity-Heinzbodyinhibition-Thaiplants-TerminaliacitrinaAsianPacificJCancerPrev,6,458-463Introductionradical-generatingage
6、nts,suchasbenzoylperoxidearetumorpromotersinmouseskin,whileconversely,someradicalPlantshaveplayedacrucialroleinmaintaininghumanscavengerscancounteractthem(Perchelletetal.,1995).healthandimprovingthequalityofhumanlifeforthousandsCancerisoneofthemostcommoncausesofdeathinofyears.Alsotherear
7、evaluablecomponentsofseasonings,Thailand.Recently,resistancetoanticancerdrugshasbeenbeverages,cosmetics,dyes,andmedicines.TheWorldobserved.ManychemicalsubstancesderivedfromherbsareHealthOrganizationhasestimatedthat80%oftheearth'sknowntobeeffectivechemopreventiveandanti-tu
