种磺胺标准品

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1、表122种磺胺标准品Table1Thestandardcompoundsof22sulfonamides结构式StructureROR磺胺名称12分子式分子量CASpKaSulfonamidesNSNFormulaMWHOHR1R2NH磺胺胍H57-67-011.3C7H10N4O2S214.24SulfaguanidineHCNH2磺胺HH63-74-110.4C6H8N2O2S172.20SulfanilamideN磺胺嘧啶H68-35-96.5C10H10N4O2S250.28SulfadiazineNCH3磺胺二甲异嘧啶HN515-64-07.4C12H14N4O2

2、S278.33SulfisomidineNCH3磺胺醋酰OH144-80-95.4C8H10N2O3S214.24SulfacetamideHCCH3S磺胺噻唑H72-14-07.2C9H9N3O2S2255.32SulfathiazoleNN磺胺吡啶H144-83-28.4C11H11N3O2S249.29SulfapyridineCH3磺胺甲基嘧啶NH127-79-77.0C11H12N4O2S264.30SulfamerazineNN磺胺对甲氧嘧啶HOCH3651-06-96.7C11H12N4O3S280.30SulfameterNCH3O磺胺二甲噁唑H729-99

3、-77.2C11H13N3O3S267.30SulfamoxoleNCH3CH3N磺胺二甲嘧啶H57-68-17.4C12H14N4O2S278.33SulfamethazineNCH3CH3S磺胺甲噻二唑H144-82-15.5C9H10N4O2S2270.33SulfamethizoleNN磺胺甲氧哒嗪HOCH380-35-36.7C11H12N4O3S280.30SulfamethoxypyridazineNNS琥珀酰磺胺噻唑OOH2H2116-43-8-C13H13N3O5S2355.39SuccinylsulfathiazoleOHCCCCHN磺胺氯哒嗪HCl80

4、-32-05.9C10H9ClN4O2S284.72SulfachloropyridazineNNCH3磺胺甲基异噁唑H723-46-66.0C10H11N3O3S253.28SulfamethoxazoleONN磺胺间甲氧嘧啶NH1220-83-36.5C11H12N4O3S280.30SulfamonomethoxineOCH3N磺胺邻二甲氧嘧啶NH2447-57-65.9C12H14N4O4S310.33SulfadoxineH3COOCH3H3CCH3磺胺二甲异噁唑H127-69-55.0C11H13N3O3S267.30SulfisoxazoleNOOCH3N磺胺

5、间二甲氧嘧啶HN122-11-26.3C12H14N4O4S310.33SulfadimethoxineOCH3磺胺喹噁啉NH59-40-55.5C14H12N4O2S300.34SulfaquinoxalineN磺胺硝苯ONO2122-16-714.5C14H13N3O5S335.34SulfanitranH3CCH2.2色谱条件WatersACQUITYUPLCBEHC18柱（1.7µm,2.1mm×50mm）；流动相：甲醇（A）和0.1%甲酸水溶液（B），梯度洗脱程序：0~2.6min，5%A~16%A；2.6~3.8min，16%A~22%A；3.8~4.8min，

6、22%A~25%A；4.8~6.6min，25%A；6.6~7.0min，25%A~55%A；7.0~9.2min，55%A~95%A；9.2~10.0min，95%A，10.0~11.0min，95%A~8%A；流速0.2mL/min；柱温30℃；样品室温度20℃；进样量5µL。2.3质谱条件电喷雾离子源；正离子扫描；毛细管电压3.5kV；射频透镜电压0.0V；离子源温度120℃；去溶剂气温度350℃；去溶剂气流量500L/h；锥孔气流量50L/h；光电倍增器电压650V；碰撞气体为氩气，碰撞-3气压3.2×10mbar；多反应监测（MRM）模式检测，22种磺胺的质谱分析

7、参数见表2。表222种磺胺的质谱分析参数Table2MSparametersfor22sulfonamidesanalysis保留时间监测离子对锥孔电压碰撞能量磺胺名称RetentiontimeMonitoringionpairsConeCollisionSulfonamides(min)(m/z)voltage(V)Energy(eV)磺胺胍215.8/108.622230.89Sulfaguanidine215.8/156.92215磺胺173.2/91.415180.99Sulfanilamide173.2/