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1、ChineseJournalofNewDrugs2003,Vol.12No.2中国新药杂志2003年第12卷第2期[5]RosenbergGA,MUN-BryceS,WesleyM,etal.Colagenase-in-[7]毛春,张苏明.镁对缺血性脑损伤的神经保护作用[J].国外医ducedintracerebralhemorrhageinrats[J].Stroke,1990,21(5)B学#脑血管疾病分册,2000,8(1)B31-34.801-807.[8]朱志安,冯东福,张红,等.硫酸镁对大鼠脑损伤后血
2、脑屏障通[6]BedersonJB,PittsLH,NishimuraMC,etal.Ratmiddlecerebral透性的影响[J].急诊医学,2000,9(1)B11-13.arteryocclusion:evaluationofthemodelanddevelopmentofaneurologicexamination[J].Stroke,1986,17(3)B472-476.(收稿日期:2002-09-23修回日期:2003-01-20)京尼平苷和西红花酸保肝利胆作用的比较彭婕,钱之玉,刘同征,饶淑云,
3、曲斌(中国药科大学药理教研室,南京210009)[摘要]目的:比较栀子果实中的2个主要有效成分京尼平苷和西红花酸的保肝利胆作用。方法:采用十二指肠给药,观察京尼平苷和西红花酸对大鼠胆汁流量的影响。采用小鼠CCl4,对乙酰氨基酚急性肝损伤模型,比较2种药物对血清丙氨酸转氨酶(ALT),天冬氨酸转氨酶(AST)及肝组织中丙二酰二醛(MDA),还原型谷胱甘肽-1(GSH),谷胱甘肽过氧化物酶(GSH-Px)的影响。结果:京尼平苷50和100mg#kg剂量于给药后0.5h均显著增加大鼠胆汁分泌,而西红花酸同样2个剂量于给
4、药后1h对大鼠胆汁分泌却有抑制作用。京尼平苷和西红花酸均可对抗CCl4和对乙酰氨基酚肝损伤引起的MDA升高,GSH含量下降和GSH-Px活力降低。肝组织的病理变化也有明显减轻,但京尼平苷的作用明显强于西红花酸。结论:栀子利胆保肝的有效成分主要为京尼平苷。[关键词]京尼平苷;西红花酸;利胆;保肝[中图分类号]R285.5[文献标识码]A[文章编号]1003-3734(2003)02-0105-04Comparativestudiesonhepaticprotectiveandcholereticeffectofge
5、niposideandcrocetinPENGJie,QIANZh-iyu,LIUTong-zheng,RAOShu-yun,QUBin(DepartmentofPharmacology,ChinaPharmaceuticalUniversity,Nanjing210009,China)[Abstract]Objective:Tocomparetheeffectsofgeniposideandcrocetin,twomainprinciplesfromGardeniajasminiodesEillis,onthe
6、bilesecretioninratsandliverinjuryinmice.Methods:Thebileflowrateofratswasobservedafterintraduodentaladministrationofgeniposideandcrocetin.BothdrugswereadministratedigtomicewithliverinjuryinducedbyCCl4andacetaminophen(AAP).Ef-fectsofbothdrugsonALT,ASTinserumand
7、MDA,GSH,GSH-Pxactivityinliverofmicewereob-servedandcompared.Liversectionsweremadeforpathologicalexamination.Results:Geniposideat-1dosesof50and100mg#kgcouldsignificantlyincreasethebilesecretionwhilethesamedosesofcro-cetindecreasedit.Geniposidecoulddecreaseseru
8、mALTandASTlevelinCCl4andAAPliverinjurymicewhilecrocetinshowednosucheffects.BothdrugscouldinhibittheincreaseofMDA,decreaseofGSHandGSH-PxactivityinCCl4andAAPliverinjurymodels.Histologicalde
