《癌基因与抑癌基因》PPT课件

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1、oncogene&tumorsuppressorgeneDepartmentofBiochemistryandmolecularbiologyZhangYingOVERVIEWManygenesandfactorsoutsideofgenesisinvolvedincarcinogenesis.Theaccumulationofmany geneticchanges causecancerotherthanmutations ofasingle gene by causingdisorders ofcell

2、growthanddifferentiation,the cellproliferation outofcontrol.Oncogene, antioncogene, tumormetastasisgene, cellapoptosis, DNAdamageandrepair,telomerase,microRNARelationshipsofoncogene, tumorsuppressorgene andgrowthfactorsoncogenetumorsuppressorgenecellsGrowt

3、hfactorPositiveregulationNegativeregulationproductsTheregulationofgeneexpressionand cellproliferation,differentiationisinvolvedinthemechanismofoncogenes andtumorsuppressorgenesSectionIOncogeneConceptofoncogeneViraloncongeneCellularoncogeneTheproductsofonco

4、ngeneanditsfuction一、theconceptofoncogeneOncogene：thegenesincellsisresponsibleofcontrollingcell growth, proliferationanddifferentiation.Theywillcause cellular canceration whentheirstructureorexpressionturnsabnormal.Allofgeneswhichencodeforgrowthfactors,gro

5、wthfactorreceptors,signalmoleculesandtranscriptionfactorsrelatedtogrowth.Thewritingofoncogeneras、src、mycv-rasc-rasClassificationofoncogene1、virusoncogenes，v-onc:thegenesexistinginvirus(mostly,retrovirus)whichcausethetargetcellsmaliganttransformation,suchas

6、v-src2、Proto-oncogenesorcellular-oncogene,c-onc:theoncogenesexistinginnormalgenomewhichareinquiescenceorinactivestatesuchasc-myc、c-ras、c-src。Undernormalcondition，thesegenesareinquiescenceorlowexpressionstateandnotonlynoharmfultocellsbutalsohelpfultostainno

7、rmalfunctiontocells.Thestructuralcomparisonofc-srcandv-src二、VirusoncogenestheoncogeneexistinginvirusgenomewhichdoesnotencodetheproteinofvirursandisnothelpfultoreplicationbutdomakehostcellContinuousproliferationRousPeytonRous肉瘤thestructureofRoussarcomavirus

8、1970,TeminandBatimore,reversetranscriptase，1975Nobel1971,Duesberg,thegenomeofRSVgagLTRpolenvLTR5’NormalvirusgeneoncogeneregulatingandinitiatingtranscriptionthecoreproteinofvirusreversetranscriptaseandIntegras