包膜恩诺沙星在猪上的临床应用分析

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1、万方数据AbstractEnrofloxacinist}le3rdgenerationFluoroquinolonesspecialforaIliIllals，belongingtobroadspectnlIIlbactericide．ItiswidelvusedfortreatmentofanimalsinEuroDea11dAmerica．ButEIlronoxacinis1imitusedbecauseofitsnanlralbinemessajldalkalinitvfordirectlVfeedingand

2、waterdrim：协g．TosolvetheEIlronoxacin‘sbittemessand2Llkalillitvproblemtorealizeoraladmilljs仃ation，tlleMicroencapsulatedEIlrofloxacinisdeveloped．Inordertoinvestigationtheclinjcalef：I、ectsoftllis够peofEnronoxacill，meinvivopharmacokineticsofEnronoxacini11swineisdete肌

3、inedbyHPLC，a11destablishedt11eswineInl’ectiousP{europneumoniamodelb、’challengingbncteriaseedin、ritro．Andthentheswinediagnosisedtreatedwithd谒、erentdosageofEnrofloxacinf10mg／l

4、n订01．Theresultsa1_eas内llows．1)．BothofMicroencapsulatedE11ronoxacinandEnrofloxacinpowderwereaccordwithaone．compartm锄tmodejwith矗rst—01．derabso印tion．21．In10mg／kg·bwora】MicroencapsulatedEnronoxacingroup，theresultshowsTtl，dxwas4．55h、C。。、was1．08“g·mL～．AUCwas14．67mg．h

5、‘L～，andT1／2kBwas4．82h。CompafedwithEnro韩oxacillpowder．therelatiVebioaVailabil毋ofMicroencapsLllatedEnro士10xacin、vas96．13％．iⅥicroencapsulatedEnronoxacinshowedgood￡lbsoIptionrateaJldbioavailabilit)r．3j．Bothofl0m坚／k芷and5mg／k譬MicroencapsuIatedEnroiloxaeine矗'ec五velyde

6、cl^easedthepi91et‘sdeathratecausedbvInfectiousPIeul．op玎eumoniaconlparedwiththedrugcontr01譬roup．Andtheef灸ctKe豫teandc砒eratewereupto90％．Thecurerateot1()nlg／kg．5mg／kggroupandthedrugconn’。lgroLlpwej’esjglli6cantjyh适herthan2．5mg，kggroupandposiLivecontroi譬roup(P<二二O．0

7、5)：Thedif凳renceofcureracebetween5mg厂kggroupanddru2contfolgroupwasn(虹si望nificanti、1(P>O．05)．4)．6．48ha毵e】‘nled论afiontreatrnent，ingrou芦of】Omg以(gand5mg／kgMicroencapsulatedEnronoxacinandthedrugcontrol‘significantlyreducedthebodytemperat珊econlpal’edwnhcontr01擘oup(P<0

8、．05)，a11dsign弧cant】yimproVdweightgaincompal．edwithcontro{groupand2．5mg瓜ggroup(P0．