多糖衍生物手性固定相分离对映体分析

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1、浙江工业大学硕士学位论文S7rUDYOFENANTIoSEPARATIoNUSINGPoLYSAC．CHARIDEDERI、厂ATIVECH【IiAI，STp汀IONARYPHASEAbstractManyenantiomersofchiralpharmaceuticalsandpesticidesshowdifferentbiologicalactivitiesandtoxicity,SOtheseparationofenantiomersisveryimportant．Theenantioseparati

2、onofseveraltypicalchiralpharmaceuticalsandpesticideswasinvestigatedoncommercialpolysaccharide-derivativechiralstationaryphasesandself-preparedcellulose-derivativechiralstationaryphasesusinghighperformanceliquidchromatography．Infirstpart，usingg,4’一methylened

3、iphenyldiisocyanate鹊bondingspacer,cellulosebenzoate(bonded—CTB)andcellulose3,5一dimethylphenybcarbamate(bonded-CDMPC)werebondedtoaminopropylsilicagelat6-position,thepreparationofbonded-CTBanditsapplicationofenantioseparationhavenotseenliteraturereportatprese

4、nt．Theself-preparedchiralstationaryphaseswerecharacterizedbyFT-IR,andtheenantioseparationofbenzoin，trans-stilbeneoxideandtroger’SbaseWasstudied011self-preparedcolumns，and011bonded—CDMPCgetberetseparation．h1thesecondpart,theherbicidenaproanilideWasseparatedo

5、nChiralcelOD，OJandself-preparedcolumns．TheinfluenceofmobileIII浙江工业大学硕士学位论文phaseadditives，concentrationandtemperatureontheenantioseparationwasstudied，andthetwoself-preparedcolumnscanusewithtetrahydrofuran(THF)asmobilephasemodifier,especiallynaproanilidecange

6、tbaselineseparationonbondedcellulosebenzoate，itCanbeusedforquantitativeanalysisofnaproanilideenantiomers．Inthethirdpart，thechiralseparationof2,3-diaryl一5一chloromethyl一1，3一oxazolidinesand2-(4’一nitro)一aryl，3．aryl．5．chloromethyl-1，3。oxazolidineswasperformedonc

7、hiralcelOD，chiralpakADandChiralpakAS．OnChiralcelOD，thefourisomersof2,3一diaryl-5一chloromethyl一1，3一oxazolidinesgotbaselineseparation，andonChiralpakADthereWaSnoseparationofenantiomers，andonChiralpakAStheenantiomerwereseparated；duetothenitryl，theinteractionbetw

8、een2一(4'-nitro)一aryl，3-aryl一5一chloromethyl一1，3一oxazolidinesandCSPsCanformstrong兀-兀interaction,andonChiralpakADtheretentiontimeWaslongest，andtheelutionsequenceWasalsodifferentfromtheothercolumns．Inthefi